IL-8 promotes cell migration through regulating EMT by activating the Wnt/β-catenin pathway in ovarian cancer

被引：76

作者：

Wen, Jirui ^{[1
,2
]}

Zhao, Zhiwei ^{[2
]}

Huang, Liwei ^{[3
]}

Wang, Ling ^{[1
]}

Miao, Yali ^{[4
]}

Wu, Jiang ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Deep Underground Space Med Ctr, 37 Guoxuexiang, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Sch Stomatol Med, Chengdu, Sichuan, Peoples R China

[4] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Dept Obstet & Gynecol,MOE, 17,3rd Sect,Renmin Nanlu Rd, Chengdu, Sichuan, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 02期

关键词：

epithelial-mesenchymal transition; interleukin-8; migration; ovarian cancer; Wnt; beta-catenin pathway; EPITHELIAL-MESENCHYMAL TRANSITION; STEM-LIKE CELLS; UP-REGULATION; E-CADHERIN; EXPRESSION; GROWTH; INVASION; WNT5A; IDENTIFICATION; METASTASIS;

D O I：

10.1111/jcmm.14848

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-8 (IL-8), as an inflammatory chemokine, has been previously shown to contribute to tumorigenesis in several malignancies including the ovarian cancer. However, little is known about how IL-8 promotes the metastasis and invasion of ovarian cancers cells. In this study, we found that IL-8 and its receptors CXCR1 and CXCR2 were up-regulated in advanced ovarian serous cancer tissues. Furthermore, the level of IL-8 and its receptors CXCR1 and CXCR2 expression were associated with ovarian cancer stage, grade and lymph node metastasis. In vitro, IL-8 promoted ovarian cancer cell migration, initiated the epithelial-mesenchymal transition (EMT) program and activated Wnt/beta-catenin signalling. However, when treated with Reparixin (inhibitor of both IL-8 receptors CXCR1 and CXCR2), effect of both endogenous and exogenous IL-8 was reversed. Together, our results indicated that IL-8 triggered ovarian cancer cells migration partly through Wnt/beta-catenin pathway mediated EMT, and IL-8 may be an important molecule in the invasion and metastasis of ovarian cancer.

引用

页码：1588 / 1598

页数：11

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