Dual Tasking and Working Memory in Alcoholism: Relation to Frontocerebellar Circuitry

被引:50
作者
Chanraud, Sandra [1 ,2 ]
Pitel, Anne-Lise [1 ]
Rohlfing, Torsten [2 ]
Pfefferbaum, Adolf [1 ,2 ]
Sullivan, Edith V. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] SRI Int, Neurosci Program, Menlo Pk, CA 94025 USA
关键词
brain; alcoholism; MRI; cerebellum; frontal cortex; working memory; COGNITIVE DEFICITS; CEREBELLAR LOOPS; CEREBRAL-CORTEX; PERFORMANCE; MOTOR; PATTERNS; SCHIZOPHRENIA; INTERFERENCE; DYSFUNCTION; ACTIVATION;
D O I
10.1038/npp.2010.56
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Controversy exists regarding the role of cerebellar systems in cognition and whether working memory compromise commonly marking alcoholism can be explained by compromise of nodes of corticocerebellar circuitry. We tested 17 alcoholics and 31 age-matched controls with dual-task, working memory paradigms. Interference tasks competed with verbal and spatial working memory tasks using low (three item) or high (six item) memory loads. Participants also underwent structural MRI to obtain volumes of nodes of the frontocerebellar system. On the verbal working memory task, both groups performed equally. On the spatial working memory with the high-load task, the alcoholic group was disproportionately more affected by the arithmetic distractor than were controls. In alcoholics, volumes of the left thalamus and left cerebellar Crus I volumes were more robust predictors of performance in the spatial working memory task with the arithmetic distractor than the left frontal superior cortex. In controls, volumes of the right middle frontal gyrus and right cerebellar Crus I were independent predictors over the left cerebellar Crus I, left thalamus, right superior parietal cortex, or left middle frontal gyrus of spatial working memory performance with tracking interference. The brain-behavior correlations suggest that alcoholics and controls relied on the integrity of certain nodes of corticocerebellar systems to perform these verbal and spatial working memory tasks, but that the specific pattern of relationships differed by group. The resulting brain structure-function patterns provide correlational support that components of this corticocerebellar system not typically related to normal performance in dual-task conditions may be available to augment otherwise dampened performance by alcoholics. Neuropsychopharmacology (2010) 35, 1868-1878; doi: 10.1038/npp.2010.56; published online 21 April 2010
引用
收藏
页码:1868 / 1878
页数:11
相关论文
共 70 条
[61]   Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies [J].
Stoodley, Catherine J. ;
Schmahmann, Jeremy D. .
NEUROIMAGE, 2009, 44 (02) :489-501
[62]   Pattern of motor and cognitive deficits in detoxified alcoholic men [J].
Sullivan, EV ;
Rosenbloom, MJ ;
Pfefferbaum, A .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2000, 24 (05) :611-621
[63]   Compromised pontocerebellar and cerebellothalamocortical systems: Speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism [J].
Sullivan, EV .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2003, 27 (09) :1409-1419
[64]   Patterns of content, contextual, and working memory impairments in schizophrenia and nonamnesic alcoholism [J].
Sullivan, EV ;
Shear, PK ;
Zipursky, RB ;
Sagar, HJ ;
Pfefferbaum, A .
NEUROPSYCHOLOGY, 1997, 11 (02) :195-206
[65]   Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: Relationships to changes in brain structure [J].
Sullivan, EV ;
Rosenbloom, MJ ;
Lim, KO ;
Pfefferbaum, A .
NEUROPSYCHOLOGY, 2000, 14 (02) :178-188
[66]   Localization of executive functions in dual-task performance with fMRI [J].
Szameitat, AJ ;
Schubert, T ;
Müller, K ;
von Cramon, DY .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2002, 14 (08) :1184-1199
[67]   fMRI measurement of brain dysfunction in alcohol-dependent young women [J].
Tapert, SF ;
Brown, GG ;
Kindermann, SS ;
Cheung, EH ;
Frank, LR ;
Brown, SA .
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2001, 25 (02) :236-245
[68]   PATTERNS OF COGNITIVE IMPAIRMENT AMONG ALCOHOLICS - ARE THERE SUBTYPES [J].
TIVIS, R ;
BEATTY, WW ;
NIXON, SJ ;
PARSONS, OA .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1995, 19 (02) :496-500
[69]   Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain [J].
Tzourio-Mazoyer, N ;
Landeau, B ;
Papathanassiou, D ;
Crivello, F ;
Etard, O ;
Delcroix, N ;
Mazoyer, B ;
Joliot, M .
NEUROIMAGE, 2002, 15 (01) :273-289
[70]   Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm [J].
Zhang, YY ;
Brady, M ;
Smith, S .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2001, 20 (01) :45-57