Prefrontal control of fear: more than just extinction

被引:456
作者
Sotres-Bayon, Francisco [1 ]
Quirk, Gregory J.
机构
[1] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
关键词
CONDITIONED FEAR; BASOLATERAL AMYGDALA; IMPAIRS CONSOLIDATION; SELECTIVE ACTIVATION; PRELIMBIC CORTEX; LEARNED FEAR; NEURONS; EXPRESSION; MEMORY; BDNF;
D O I
10.1016/j.conb.2010.02.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues.
引用
收藏
页码:231 / 235
页数:5
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