Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues.
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Bredy, Timothy W.
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Wu, Hao
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机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Wu, Hao
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Crego, Cortney
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机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Crego, Cortney
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Zellhoefer, Jessica
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机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Zellhoefer, Jessica
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Sun, Yi E.
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机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Sun, Yi E.
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Barad, Mark
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机构:
Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USASemel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Bredy, Timothy W.
;
Wu, Hao
论文数: 0引用数: 0
h-index: 0
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Wu, Hao
;
Crego, Cortney
论文数: 0引用数: 0
h-index: 0
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Crego, Cortney
;
Zellhoefer, Jessica
论文数: 0引用数: 0
h-index: 0
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Zellhoefer, Jessica
;
Sun, Yi E.
论文数: 0引用数: 0
h-index: 0
机构:Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Sun, Yi E.
;
Barad, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Semel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USASemel Inst Neurosci & Human Behav, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA