Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

被引：88

作者：

Koch, Eva ^{[1
]}

Takise, Ryosuke ^{[2
,3
]}

Studer, Armido ^{[1
]}

Yamaguchi, Junichiro ^{[2
,3
]}

Itami, Kenichiro ^{[2
,3
,4
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

[2] Nagoya Univ, Grad Sch Sci, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[3] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[4] Nagoya Univ, Itami Mol Nanocarbon Project, JST,ERATO, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 05期

关键词：

C-O BOND; ARYL HALIDES; SUZUKI-MIYAURA; AZOLES; CARBONYL; ACTIVATION; VINYLATION; OXINDOLES; CLEAVAGE; ETHERS;

D O I：

10.1039/c4cc08426h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nickel-catalyzed alpha-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)(2), 3,4-bis(dicyclohexyl-phosphino) thiophene (dcypt), and K3PO4, various esters and amides undergo alpha-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained alpha-aryl esters and amides are useful precursors of privileged motifs such as alpha-arylcarboxylic acids and beta-arylamines.

引用

页码：855 / 857

页数：3

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