Impact of the discovery of human zinc deficiency on health

被引：139

作者：

Prasad, Ananda S. ^{[1
,2
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI 48201 USA

[2] Karmanos Canc Ctr, Detroit, MI 48201 USA

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2014年 / 28卷 / 04期

关键词：

Zinc; Growth retardation; Immunity; Antioxidant; Anti-inflammatory agent; OXIDATIVE STRESS; ACRODERMATITIS-ENTEROPATHICA; INFLAMMATORY CYTOKINES; DOUBLE-BLIND; DISEASE; SUPPLEMENTATION; DURATION; HYPOGONADISM; INFECTIONS; GENERATION;

D O I：

10.1016/j.jtemb.2014.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：357 / 363

页数：7

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