Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo

被引：45

作者：

Li, Maoxing ^{[1
]}

Shang, Xiaofei ^{[2
]}

Zang, Ruxue ^{[1
]}

Jia, Zhengping ^{[1
,2
]}

Fan, Pengcheng ^{[1
]}

Ying, Qiang ^{[1
]}

Wei, Lili ^{[1
]}

机构：

[1] Lanzhou Gen Hosp PLA, Dept Pharm, Lanzhou 730050, Peoples R China

[2] Lanzhou Univ, Dept Life Sci, Lanzhou 730000, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 03期

关键词：

Lamiophlomis rotata; Iridoid glycoside; Antinociceptive activity; Anti-inflammatory activity; FORMALIN TEST; ANALGESIC ACTIVITY; AQUEOUS EXTRACT; MICE;

D O I：

10.1016/j.fitote.2009.08.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lamtophlomis rotata (Benth ) Kudo is a perennial herb (Labiatae) used as the Tibetan traditional medicine with the effects of alleviating pain, detumescence, hemostasis, promoting blood circulation to remove blood stasis and reinforcing marrow In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times. Inhibit carrageenam-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice All of these results suggested that the iridoid glycosides extract possesses the significant antinociceptive and anti-inflammatory activities (C) 2009 Elsevier B V All rights reserved

引用

页码：167 / 172

页数：6

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