Rodent anxiety and kindling of the central amygdala and nucleus basalis

被引:18
作者
Adamec, R [1 ]
Shallow, T [1 ]
机构
[1] Mem Univ Newfoundland, Dept Psychol, St John, NF A1B 3X9, Canada
关键词
anxiety; elevated plus maze; lasting change; kindling; central amygdala; focus location; nucleus basalis; rat; risk assessment;
D O I
10.1016/S0031-9384(00)00250-X
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
We studied lasting behavioral effects of kindling of three parts of the central nucleus of the amygdala and the anterior nucleus basalis in the right hemisphere of male Wistar rats. Kindling lastingly changed two measures of anxiety in the elevated plus-maze. The nature of the change depended on the location of the kindled focus. Kindling of the posterior central nucleus decreased both open-arm exploration and frequency of risk assessment in the elevated plus-maze 1 week after the fourth stage 5 seizure. Kindling of the middle parts of the central nucleus was without behavioral effects. Kindling of the anterior central nucleus and the anterior nucleus basalis increased risk assessment, which was interpreted as an anxiolytic effect. Changes in risk assessment produced by kindling of the central nucleus were dependent on open-arm avoidance, whereas the effects of nucleus basalis kindling were independent of open-arm avoidance. Analysis of covariance and factor analysis support the view that control of risk assessment is by circuitry, which is independent of that which controls open-arm avoidance. Moreover, part of this circuitry appears to involve the anterior nucleus basalis. Changes in plus-maze behavior were independent of changes in exploration or activity in either the plus-maze or hole board. These findings add to a growing body of evidence that suggests that subtle differences in location of a kindled focus within the rat amygdala lead to different behavioral outcomes. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:177 / 187
页数:11
相关论文
共 62 条
[1]   Neural plasticity, neuropeptides and anxiety in animals - implications for understanding and treating affective disorder following traumatic stress in humans [J].
Adamec, R ;
Kent, P ;
Anisman, H ;
Shallow, T ;
Merali, Z .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1998, 23 (02) :301-318
[2]  
ADAMEC R, 1994, TOXICOL IND HEALTH, V10, P391
[4]  
Adamec R, 1998, ADV BEHAV BIOL, V48, P327
[5]  
ADAMEC R, 1991, PHYSIOL REV, V49, P43
[6]  
Adamec R E, 1990, Neuroreport, V1, P255, DOI 10.1097/00001756-199011000-00022
[7]   LASTING EFFECTS OF FG-7142 ON ANXIETY, AGGRESSION AND LIMBIC PHYSIOLOGY IN THE CAT [J].
ADAMEC, RE .
JOURNAL OF PSYCHOPHARMACOLOGY, 1993, 7 (03) :232-248
[8]  
Adamec RE, 1999, PHYSIOL BEHAV, V65, P739
[9]   AMYGDALA KINDLING, ANXIETY, AND CORTICOTROPIN-RELEASING FACTOR (CRF) [J].
ADAMEC, RE ;
MCKAY, D .
PHYSIOLOGY & BEHAVIOR, 1993, 54 (03) :423-431
[10]   PARTIAL LIMBIC KINDLING - BRAIN, BEHAVIOR, AND THE BENZODIAZEPINE RECEPTOR [J].
ADAMEC, RE .
PHYSIOLOGY & BEHAVIOR, 1993, 54 (03) :531-545