Intracellular trafficking of ceramide by ceramide transfer protein

被引：74
|
作者：
Hanada, Kentaro [1 ]
机构：
[1] Natl Inst Infect Dis, Dept Biochem & Cell Biol, Shinjuku Ku, Tokyo 1628640, Japan
来源：
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2010年 / 86卷 / 04期
基金：
日本学术振兴会;
关键词：
ceramide; sphingomyelin; endoplasmic reticulum; Golgi; lipid transport; ANTIGEN-BINDING PROTEIN; ACUTE REGULATORY PROTEIN; ENDOPLASMIC-RETICULUM; GOODPASTURE ANTIGEN; NONVESICULAR TRAFFICKING; SPHINGOMYELIN SYNTHESIS; SPLICED VARIANT; START DOMAIN; GOLGI; TRANSPORT;
D O I：
10.2183/pjab.86.426
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin. Ceramide transfer protein (CERT) mediates the ER-to-Golgi trafficking of ceramide. It has been suggested that CERT extracts ceramide from the ER and carries it to the Golgi apparatus in a non-vesicular manner and that efficient CERT-mediated trafficking of ceramide occurs at membrane contact sites between the ER and the Golgi apparatus.
引用
收藏
页码：426 / 437
页数：12
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