Rationale for Nicotinamide Adenine Dinucleotide (NAD+) Metabolome Disruption as a Pathogenic Mechanism of Post-Acute COVID-19 Syndrome

被引:9
作者
Block, Tabitha [1 ]
Kuo, Jonathann [1 ]
机构
[1] Hudson Med Grp, New York, NY USA
来源
CLINICAL PATHOLOGY | 2022年 / 15卷
关键词
SARS virus; NAD; oxidative stress; mitochondria; metabolome; Coronavirus infections; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; NAD(+); SUPPLEMENTATION; PATHWAYS; MODEL; PLUS;
D O I
10.1177/2632010X221106986
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Many acute COVID-19 convalescents experience a persistent sequelae of infection, called post-acute COVID-19 syndrome (PACS). With incidence ranging between 31% and 69%, PACS is becoming increasingly acknowledged as a new disease state in the context of SARS-CoV-2 infection. As SARS-CoV-2 infection can affect several organ systems to varying degrees and durations, the cellular and molecular abnormalities contributing to PACS pathogenesis remain unclear. Despite our limited understanding of how SARS-CoV-2 infection promotes this persistent disease state, mitochondrial dysfunction has been increasingly recognized as a contributing factor to acute SARS-CoV-2 infection and, more recently, to PACS pathogenesis. The biological mechanisms contributing to this phenomena have not been well established in previous literature; however, in this review, we summarize the evidence that NAD+ metabolome disruption and subsequent mitochondrial dysfunction following SARS-CoV-2 genome integration may contribute to PACS biological pathogenesis. We also briefly examine the coordinated and complex relationship between increased oxidative stress, inflammation, and mitochondrial dysfunction and speculate as to how SARS-CoV-2-mediated NAD+ depletion may be causing these abnormalities in PACS. As such, we present evidence supporting the therapeutic potential of intravenous administration of NAD+ as a novel treatment intervention for PACS symptom management.
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页数:6
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