Pyogenic Liver Abscess Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide, Population-Based Cohort Study

被引：9

作者：

Wang, Tzu-Yuan ^{[1
,2
]}

Lai, Hsueh-Chou ^{[3
]}

Chen, Hsin-Hung ^{[4
,5
,6
]}

Wang, Mei-Lin ^{[7
]}

Hsieh, Ming-Chia ^{[1
]}

Chang, Chwen-Tzuei ^{[1
]}

Chen, Rong-Hsing ^{[1
]}

Ho, Chun-Wei ^{[1
]}

Hung, Yi-Chin ^{[1
]}

Tseng, Juei-Yu ^{[1
]}

Lin, Cheng-Li ^{[8
,9
]}

Kao, Chia-Hung ^{[10
,11
,12
,13
,14
]}

机构：

[1] China Med Univ Hosp, Intelligent Diabet Metab & Exercise Ctr, Dept Internal Med, Taichung, Taiwan

[2] China Med Univ, Sch Med, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Internal Med, Div Hepatogastroenterol, Taichung, Taiwan

[4] Asia Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

[5] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[6] Chung Sheng Clin, Nantou, Taiwan

[7] Hung Kuang Univ, Dept Nursing, Taichung, Taiwan

[8] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[9] China Med Univ, Coll Med, Taichung, Taiwan

[10] China Med Univ, Grad Inst Biomed Sci Sci, Sch Med, Coll Med, Taichung, Taiwan

[11] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[12] China Med Univ Hosp, Positron Emiss Tomog PET Ctr, Taichung, Taiwan

[13] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

[14] China Med Univ Hosp, Ctr Augmented Intelligence Healthcare, Taichung, Taiwan

来源：

FRONTIERS IN MEDICINE | 2021年 / 8卷

关键词：

pyogenic liver abscess; newly diagnosed type 2 diabetic mellitus; Klebsiella pneumonia; acarbose; National Health Insurance Research Database; KLEBSIELLA-PNEUMONIAE; HEPATIC TUBERCULOSIS; COMMON INFECTIONS; PRIMARY-CARE; EPIDEMIOLOGY; BACTEREMIA;

D O I：

10.3389/fmed.2021.675345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: To date, no comprehensive epidemiological study exists on pyogenic liver abscess (PLA) risk in patients with newly diagnosed type 2 diabetes mellitus (T2DM) worldwide. Methods: We conducted a retrospective cohort study by using data from Taiwan National Health Insurance Research Database (NHIRD) to examine the association between newly diagnosed T2DM and PLA. The T2DM cohort included patients newly diagnosed as having T2DM (ICD-9-CM:250) from 2000 to 2009, with follow-up until December 31, 2011. The comparison cohort was then recruited through 1:4 random frequency matching with the T2DM cohort. Finally, the adjusted hazard ratios for PLA were compared between the T2DM and comparison cohorts, which included 44,728 patients with T2DM and 178,912 patients without DM respectively. Results: In T2DM cohort, 166 patients were diagnosed as having PLA (incidence rate = 5.87 per 10,000 person-years) and in comparison cohort, 238 patients were diagnosed as having PLA (incidence rate = 2.06 per 10,000 person-years). The T2DM cohort exhibited higher PLA risk than did the comparison cohort (hazard ratio = 2.83, 95% confidence interval = 2.32-3.46). Furthermore, the adjusted hazard ratio for PLA risk in T2DM cohort was the highest in those who were younger, man and with duration of DM <2 years. In the T2DM cohort, the most common PLA causative agent was Klebsiella pneumonia (KP). In addition, PLA risk was high in T2DM patients with gallstone and cholecystitis. Compared with comparison cohort, patients with T2DM prescribed acarbose has a lower PLA risk, however glyburide significantly increased PLA risk in T2DM cohort. Conclusion: In patients with newly diagnosed T2DM, PLA risk was high and acarbose might reduce PLA risk.

引用

页数：9

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