Targeted exercise therapy for voice and swallow in persons with Parkinson's disease

被引:35
作者
Russell, John A. [1 ,2 ]
Ciucci, Michelle R. [2 ]
Connor, Nadine P. [2 ]
Schallert, Timothy [3 ]
机构
[1] Univ Wisconsin, Ctr Clin Sci, Sch Med & Publ Hlth Otolaryngol Head & Neck Surg, Madison, WI 53792 USA
[2] Univ Wisconsin Madison, Dept Communicat Disorders, Madison, WI USA
[3] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA
关键词
Parkinson disease; Exercise; Voice; Swallow; Dysphagia; Dysarthria; Dopamine; Targeted training; STRIATAL MICROEXCITABLE ZONES; INTENSIVE SPEECH TREATMENT; PRIMARY MOTOR CORTEX; TREATMENT LSVT(R); BASAL GANGLIA; PRIMATE NEOSTRIATUM; BEHAVIORAL RECOVERY; PHYSICAL-ACTIVITY; LIMB-USE; RATS;
D O I
10.1016/j.brainres.2010.03.029
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sensorimotor deficits affecting voice and swallowing ability can have a devastating impact on the quality of life of people with Parkinson disease (PD). Recent scientific findings in animal models of PD pinpoint targeted exercise therapy as a potential treatment to reduce neurochemical loss and decrease parkinsonian symptoms. Although there may be beneficial effects, targeted exercise therapy is not a standard component of therapy for the cranial sensiromotor deficits seen in PD. In this paper, we review the scientific evidence for targeted training for voice and swallowing deficits. The literature search revealed 19 publications that included targeted training for voice and only one publication that included targeted training for swallowing. We summarize 3 main findings: (1) targeted training may be associated with lasting changes in voice behavior; (2) targeted training of sensorimotor actions with anatomical or functional overlap with voice and swallowing may improve voice and swallowing to some degree, but it is unknown whether these effects endure over time; and (3) evidence regarding cranial sensorimotor interventions for Parkinson disease is sparse. We concluded that targeted training for voice and swallow is a promising but understudied intervention for cranial sensorimotor deficits associated with PD and posit that animal models can be useful in designing empirically based studies that further the science on targeted training. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 11
页数:9
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