Individual differences in the expression of conditioned fear are associated with endogenous fibroblast growth factor 2

被引：10

作者：

Graham, Bronwyn M. ^{[1
]}

Richardson, Rick ^{[1
]}

机构：

[1] Univ New South Wales Australia, Sch Psychol, Sydney, NSW 2052, Australia

来源：

LEARNING & MEMORY | 2016年 / 23卷 / 01期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

ENHANCES EXTINCTION; REDUCES RENEWAL; ANXIETY; FGF2; REINSTATEMENT; ALTERS; RATS;

D O I：

10.1101/lm.039644.115

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

These experiments examined the relationship between the neurotrophic factor fibroblast growth factor 2 (FGF2) and individual differences in the expression of conditioned fear. Experiments 1 and 2 demonstrated that rats naturally expressing low levels of contextual or cued fear have higher levels of hippocampal FGF2 relative to rats that express high levels of conditioned fear and nonconditioned rats. Experiment 3 demonstrated that hippocampal FGF2 is not increased in rats that exhibit pharmacological-induced amnesia of conditioned fear. Together, these experiments provide evidence that FGF2 may be an endogenous regulator of fear responses to conditioned stimuli.

引用

页码：42 / 45

页数：4