Bone mineral density in long-term survivors of highly malignant osteosarcoma

被引：74

作者：

Holzer, G

Krepler, P

Koschat, MA

Grampp, S

Dominkus, A

Kotz, R

机构：

[1] Univ Vienna, Dept Orthopaed, Vienna Gen Hosp, A-1090 Vienna, Austria

[2] Univ Vienna, Dept Orthopaed, Vienna Gen Hosp, A-1090 Vienna, Austria

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2003年 / 85B卷 / 02期

关键词：

D O I：

10.1302/0301-620X.85B2.13257

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We studied the bone mineral density (BMD) of 48 long-term survivors of highly malignant osteosarcoma who had been treated according to the chemotherapy protocols of the German- Swiss-Austrian Co-operative Osteosarcoma Study Group which include high-dose methotrexate. The mean age of the patients was 31 +/- 4.2 years and the mean follow-up 16 +/- 2.2 years. The BMD of the lumbar spine and of the proximal femur of the non-operated side was measured by dual-energy x-ray absorptiometry. A questionnaire was given to determine life-style factors, medical history and medication. Ten patients were osteoporotic, 21 osteopenic and 17 normal according to the WHO definition. Eighteen patients suffered fractures after receiving chemotherapy and all had significantly lower levels of BMD for all the sites measured.

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页码：231 / 237

页数：7

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