ApoE influences regional white-matter axonal density loss in Alzheimer's disease

被引：79

作者：

Slattery, Catherine F. ^{[1
]}

Zhang, Jiaying ^{[2
,3
]}

Paterson, Ross W. ^{[1
]}

Foulkes, Alexander J. M. ^{[1
]}

Carton, Amelia ^{[1
]}

Macpherson, Kirsty ^{[1
]}

Mancini, Laura ^{[4
,5
]}

Thomas, David L. ^{[4
,6
]}

Modat, Marc ^{[7
]}

Toussaint, Nicolas ^{[7
]}

Cash, David M. ^{[1
,7
]}

Thornton, John S. ^{[4
,5
]}

Henley, Susie M. D. ^{[1
]}

Crutch, Sebastian J. ^{[1
]}

Alexander, Daniel C. ^{[2
,3
]}

Ourselin, Sebastien ^{[7
]}

Fox, Nick C. ^{[1
]}

Zhang, Hui ^{[2
,3
]}

Schott, Jonathan M. ^{[1
]}

机构：

[1] UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England

[2] UCL, Dept Comp Sci, London, England

[3] UCL, Ctr Med Image Comp, London, England

[4] UCL, Neuroradiol Acad Unit, Dept Brain Repair & Rehabil, Inst Neurol, London, England

[5] UCLH NHS Fdn Trust, Lysholm Dept Neuroradiol, Natl Hosp Neurol & Neurosurg, London, England

[6] UCL, Inst Neurol, Leonard Wolfson Expt Neurol Ctr, London, England

[7] UCL, Translat Imaging Grp, Ctr Med Image Comp, Dept Med Phys & Biomed Engn, London, England

来源：

NEUROBIOLOGY OF AGING | 2017年 / 57卷

基金：

英国工程与自然科学研究理事会; 欧盟第七框架计划;

关键词：

Alzheimer's disease; Diffusion tensor imaging; Neurite orientation dispersion and density; imaging; Apoe; White matter; Phenotype; NEURITE ORIENTATION DISPERSION; POSTERIOR CORTICAL ATROPHY; APOLIPOPROTEIN-E; DIFFUSION MRI; HUMAN BRAIN; SPATIAL STATISTICS; COMPARTMENT MODELS; REGISTRATION; OPTIMIZATION; PATTERNS;

D O I：

10.1016/j.neurobiolaging.2017.04.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI) with tract-based spatial statistics to investigate apolipoprotein (APOE) epsilon 4 modulation of white-matter damage in 37 patients with YOAD (22, 59% APOE e4 positive) and 23 age-matched controls. Correlation between neurite density index (NDI) and neuropsychological performance was assessed in 4 white-matter regions of interest. White-matter disruption was more widespread in epsilon 4+ individuals but more focal (posterior predominant) in the absence of an e4 allele. NODDI metrics indicate fractional anisotropy changes are underpinned by combinations of axonal loss and morphological change. Regional NDI in parieto-occipital white matter correlated with visual object and spatial perception battery performance (right and left, both p = 0.02), and performance (nonverbal) intelligence (WASI matrices, right, p = 0.04). NODDI provides tissue-specific microstructural metrics of white-matter tract damage in YOAD, including NDI which correlates with focal cognitive deficits, and APOE epsilon 4 status is associated with different patterns of white-matter neurodegeneration. (C) 2017 The Authors. Published by Elsevier Inc.

引用

页码：8 / 17

页数：10

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