Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the shortchain dehydrogenase/reductase superfamily

被引：187

作者：

Hoffmann, Frank ^{[1
]}

Maser, Edmund ^{[1
]}

机构：

[1] Univ Kiel, Sch Med, Inst Toxicol & Pharmacol Nat Scientists, D-24105 Kiel, Germany

来源：

DRUG METABOLISM REVIEWS | 2007年 / 39卷 / 01期

关键词：

reductive drug metabolism; carbonyl reductase; hydroxysteroid dehydrogenase; pluripotency; aldo-keto reductase (AKR) superfamily; short-chain dehydrogenasereductase (SDR) superfamily;

D O I：

10.1080/03602530600969440

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Carbonyl reduction of aldehydes, ketones, and quinones to their corresponding hydroxy derivatives plays an important role in the phase I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds. Carbonyl-reducing enzymes are grouped into two large protein superfamilies: the aldo-keto reductases (AKR) and the short-chain dehydrogenaseslreductases (SDR). Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs. In addition, there exist a variety of pluripotent hydroxysteroid dehydrogenases (HSDs) of both superfamilies that specifically catalyze the oxidoreduction at different positions of the steroid nucleus and also catalyze, rather nonspecifically, the reductive metabolism of a great number of nonsteroidal carbonyl compounds. The present review summarizes recent-findings on carbonyl reductases and pluripotent HSDs of the SDR protein superfamily.

引用

页码：87 / 144

页数：58

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