Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations

被引：6
作者：
Shimizu, Takuya [1 ]
Kondo, Tadakazu [1 ]
Matsumoto, Kana [2 ]
Hishizawa, Masakatsu [1 ]
Yamashita, Kouhei [1 ]
Takaori-Kondo, Akifumi [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan
[2] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Dept Clin Pharmaceut, Kyoto, Japan
来源：
TRANSPLANT INFECTIOUS DISEASE | 2019年 / 21卷 / 06期
关键词：
allogenic hematopoietic stem cell transplantation; cidofovir; intravesical; kidney transplantation; virus-associated hemorrhagic cystitis; GUIDELINES;
D O I：
10.1111/tid.13185
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We present a patient with virus-associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo-HSCT). Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.
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