The role of cytokines in atopic dermatitis: a breakthrough in immunopathogenesis and treatment

被引：9

作者：

Alsabbagh, Manahel ^{[1
]}

Ismaeel, Amina ^{[2
]}

机构：

[1] Arabian Gulf Univ, Princess Al Jawhara Ctr Mol Med & Inherited Disor, Dept Mol Med, Manama, Bahrain

[2] Arabian Gulf Univ, Coll Med & Med Sci, Dept Pathol, Manama, Bahrain

来源：

ACTA DERMATOVENEROLOGICA ALPINA PANNONICA ET ADRIATICA | 2022年 / 31卷 / 01期

关键词：

atopic dermatitis; cytokines; immunopathogenesis; T cells; interleukin; inflammatory skin disease; BLOOD MONONUCLEAR-CELLS; THYMIC STROMAL LYMPHOPOIETIN; MIGRATION INHIBITORY FACTOR; SINGLE-NUCLEOTIDE POLYMORPHISM; INTERLEUKIN-4; RECEPTOR-ALPHA; INTERFERON-GAMMA PRODUCTION; T-REGULATORY CELLS; SKIN-INFILTRATING LYMPHOCYTES; PLASMACYTOID DENDRITIC CELLS; MACROPHAGE-DERIVED CHEMOKINE;

D O I：

10.15570/actaapa.2022.3

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis is a multifactorial inflammatory skin disease with a complex immunopathogenesis that is characterized by an underlying imbalance of T-cell subsets. Although cytokines of type 2 immunity consistently predominate in the acute phase of atopic dermatitis, there is strong evidence supporting the contribution of cytokines of type 1 immunity, type 3 immunity, and other cytokines in the development and progression of the disease. This review explores the cytokine network in atopic dermatitis, and it highlights areas and causes of controversy in the immunopathogenesis of the disease. In addition, it presents the current therapeutic targets currently being investigated, including monoclonal antibodies and small molecules that inhibit cytokines and downstream signaling molecules in atopic dermatitis. We conclude that atopic dermatitis has a complex and controversial cytokine profile. Understanding the role of cytokines in the immunopathogenesis of the disease is essential for identifying personalized targets for better management and disease control.

引用

页码：13 / 31

页数：19

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