Multiblock copolymers type PDC - A family of multifunctional biomaterials for regenerative medicine

被引：1
作者：
Ullah, Imram [1 ,2 ]
Wang, Weiwei [1 ,2 ]
Ma, Nan [1 ,2 ,4 ]
Lendlein, Andreas [1 ,2 ,3 ,4 ]
机构：
[1] Helmholtz Zentrum Hereon, Inst Act Polymers, Teltow, Germany
[2] Helmholtz Zentrum Hereon, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Teltow, Germany
[3] Univ Potsdam, Inst Chem, Potsdam, Germany
[4] Free Univ Berlin, Inst Chem & Biochem, Berlin, Germany
来源：
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2022年 / 80卷 / 03期
关键词：
Multiblock copolymers PDC; biofunctionality; soft tissue regeneration; PROTEIN ADSORPTION; ENDOTHELIAL-CELLS; SMOOTH-MUSCLE; DEGRADATION; CHALLENGES; VIABILITY; ADHESION; DIFFERENTIATION; ANGIOGENESIS; ORIENTATION;
D O I：
10.3233/CH-211264
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiblock copolymers type PDC are polyetheresterurethanes composed of poly(epsilon-caprolactone) and poly(p-dioxanone) segments. They were designed as degradadable shape-memory polymers for medical devices, which can be implanted minimally-invasively. While providing structural support in the initial phase after implantation, they are capable to modulate soft tissue regeneration while degradation. In this perspective, we elucidate cell-material interactions, compatibility both in-vitro and in-vivo and biofunctionality of PDC, which represents a promising candidate biomaterial family especially for cardiovascular applications.
引用
收藏
页码：327 / 341
页数：15
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