Opiates inhibit neurogenesis in the adult rat hippocampus

被引：488
作者：
Eisch, AJ
Barrot, M
Schad, CA
Self, DW
Nestler, EJ
机构：
[1] Yale Univ, Sch Med, Lab Mol Psychiat, New Haven, CT 06508 USA
[2] Yale Univ, Sch Med, Yale Ctr Genes & Behav, New Haven, CT 06508 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 13期
关键词：
D O I：
10.1073/pnas.120552597
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, we examined opiate regulation of neurogenesis in this brain region. Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin. Opiate regulation of neurogenesis was not mediated by changes in circulating levels of glucocorticoids, because similar effects were seen in rats that received adrenalectomy and corticosterone replacement. These findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.
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页码：7579 / 7584
页数：6
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