A theoretical study of the Caputo-Fabrizio fractional modeling for hearing loss due to Mumps virus with optimal control

Mumps is the most common cause of acquired unilateral deafness in children, in which hearing loss oc-curs at all auditory frequencies. We use a box model to model hearing loss in children caused by the mumps virus, and since the fractional-order derivative retains the effect of system memory, we use the Caputo-Fabrizio fractional derivative in this modeling. In the beginning, we compute the basic reproduc-tion number R-0 and equilibrium points of the system and investigate the stability of the system at the equilibrium point. By utilizing the Picard-Lindelof technique, we prove the existence an unique solution for given fractional CF-system of hearing loss model and investigate the stability of iterative method by fixed point theory. The optimal control of the system is determined by considering the treatment as a control strategy to reduce the number of infected people. Using the Euler method for the fractional-order Caputo-Fabrizio derivative, the approximate solution of the system is calculated. We present a numerical simulation for the transmission of disease with respect to the transmission rate and the basic reproduc-tion number in two cases R-0 < 1 and R-0 > 1 . To investigate the effect of fractional order derivative on the behavior and value of each of the variables in Model 2, we calculate the results for several fractional order derivatives and compare the results. Also, considering the importance of reproduction number in the continuation of disease transmission, we analyze the sensitivity of R-0 respect to each of the model parameters and determine the impact of each parameter. (C) 2021 Published by Elsevier Ltd.