HPV Type-Specific Prevalence a Decade after the Implementation of the Vaccination Program: Results from a Pilot Study

被引:11
作者
Fappani, Clara [1 ]
Bianchi, Silvia [2 ]
Panatto, Donatella [3 ]
Petrelli, Fabio [4 ]
Colzani, Daniela [1 ]
Scuri, Stefania [4 ]
Gori, Maria [1 ]
Amendola, Antonella [1 ,5 ]
Grappasonni, Iolanda [4 ]
Tanzi, Elisabetta [1 ,5 ]
Amicizia, Daniela [3 ]
机构
[1] Univ Milan, Dept Biomed Sci Hlth, I-20133 Milan, Italy
[2] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy
[3] Univ Genoa, Dept Hlth Sci, I-16100 Genoa, Italy
[4] Univ Camerino, Sch Med & Hlth Prod Sci, I-62032 Camerino, Italy
[5] Univ Milan, Coordinated Res Ctr EpiSoMI, I-20133 Milan, Italy
关键词
HPV infection; urine samples; HPV genotype distribution; vaccine-preventable diseases; Italy; HUMAN-PAPILLOMAVIRUS; NORMAL CYTOLOGY; WOMEN; CLASSIFICATION; INFECTIONS; CANCER; DNA;
D O I
10.3390/vaccines9040336
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human papillomavirus infection is a cause of the development of invasive cervical cancer. Three types of vaccine are currently available to prevent precancerous/cancerous lesions due to persistent infection, which is supported mainly by 7 different high-risk genotypes. The aim of this pilot study was to acquire preliminary data on type-specific prevalence 10 years after the implementation of the HPV vaccination program in Italy, in order to subsequently plan appropriate observational studies in the Italian population. First-voided urine samples were collected from 393 consenting subjects, both females and males, aged 18-40 years, and HPV DNA was detected by PCR amplification of a 450 bp L1 fragment. All amplified products were genotyped by means of the Restriction Fragment Length Polymorphism (RFLP) method. The female population was divided into three cohorts ("vaccine-eligible", "pre-screening" and "screening" cohorts) according to the preventive intervention scheduled by age; males were included in the same three cohorts according to their year of birth. The overall prevalence of HPV infection was 19%, being higher in females than in males (22.1% vs. 13.6%, p = 0.03729). In the female population, 10 years after the start of the national immunization program, we observed a reduction in the prevalence of vaccine types and the number of circulating genotypes, especially in the "vaccine-eligible" cohort. The frequency of HPV vaccine types increased with age, particularly in males in the "pre-screening" and "screening" cohorts. Our study highlights the importance of monitoring HPV infection in both genders, to validate the effect of the HPV vaccination program.
引用
收藏
页数:10
相关论文
共 38 条
[1]  
[Anonymous], 2012, IARC Monographs on the evaluation of carcinogenic risks to humans-Human Papillomaviruses, V100B., P255
[2]  
[Anonymous], 2004, GENITAL HPV INFECT C
[3]   International standardization and classification of human papillomavirus types [J].
Bzhalava, Davit ;
Eklund, Carina ;
Dillner, Joakim .
VIROLOGY, 2015, 476 :341-344
[4]   Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus (HPV) with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay [J].
Cho, Hyun-Woong ;
Ouh, Yung-Taek ;
Hong, Jin Hwa ;
Min, Kyung Jin ;
So, Kyeong A. ;
Kim, Tae Jin ;
Paik, E. Sun ;
Lee, Jeong-Won ;
Moon, Jun Hye ;
Lee, Jae Kwan .
JOURNAL OF VIROLOGICAL METHODS, 2019, 269 :77-82
[5]   Self-reported sexual debut and behavior in young adults aged 48-24 years in seven European countries: Implications for HPV vaccination programs [J].
Crochard, Anne ;
Luyts, Dominique ;
di Nicola, Sylvie ;
Goncalves, M. Alice G. .
GYNECOLOGIC ONCOLOGY, 2009, 115 (03) :S7-S14
[6]   Human papillomavirus DNA and p16INK4a expression in hypopharyngeal cancer and in relation to clinical outcome, in Stockholm, Sweden [J].
Dalianis, Tina ;
Gruen, Nathalie ;
Koch, Jana ;
Vlastos, Andrea ;
Tertipis, Nikolaos ;
Nordfors, Cecilia ;
Nasman, Anders ;
Wendt, Malin ;
Romanitan, Mircea ;
Bersani, Cinzia ;
Munck-Wikland, Eva ;
Ramqvist, Torbjorn .
ORAL ONCOLOGY, 2015, 51 (09) :857-861
[7]   HPV Vaccine: Updates and Highlights [J].
de Oliveira, Cristina Mendes ;
Fregnani, Jose Humberto T. G. ;
Villa, Luisa Lina .
ACTA CYTOLOGICA, 2019, 63 (02) :159-168
[8]  
Dean AG, OpenEpi: Open Source Epidemiologic Statistics for Public Health
[9]   Effectiveness of varying number of doses and timing between doses of quadrivalent HPV vaccine against severe cervical lesions [J].
Dehlendorff, Christian ;
Sparen, Par ;
Baldur-Felskov, Birgitte ;
Herweijer, Eva ;
Arnheim-Dahlstrom, Lisen ;
Ploner, Alexander ;
Uhnoo, Ingrid ;
Kjaer, Susanne K. .
VACCINE, 2018, 36 (43) :6373-6378
[10]  
ECDC, GUID HPV VACC EU CON