Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

被引：28

作者：

Alfredo Segura-Cerda, Cristian ^{[1
,2
]}

Lopez-Romero, Wendy ^{[2
]}

Alberto Flores-Valdez, Mario ^{[2
]}

机构：

[1] Univ Guadalajara, Farmacol, Guadalajara, Mexico

[2] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Biotecnol Med & Farmaceut, Guadalajara, Mexico

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2019年 / 9卷

关键词：

Mycobacterium tuberculosis infection; type; 2; diabetes; hyperglycemia; diabetic dyslipidemia; hormones; PULMONARY TUBERCULOSIS; INSULIN-RESISTANCE; GUT MICROBIOTA; VITAMIN-D; IMPACT; MACROPHAGES; PROTEIN-3; MELLITUS; CHOLESTEROL; PROGRESSION;

D O I：

10.3389/fcimb.2019.00342

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide. Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D). Incidence of T2D is recognized as a high-risk factor that may contribute to tuberculosis dissemination. However, mechanisms which favor infection under T2D are just starting to emerge. Here, we first discuss the evidences that are available to support a metabolic connection between TB and T2D. Then, we analyze the evidences of metabolic changes which occur during T2D gathered thus far for its influence on susceptibility to M. tuberculosis infection and TB progression, such as hyperglycemia, increase of 1AC levels, increase of triglycerides levels, reduction of HDL-cholesterol levels, increased concentration of lipoproteins, and modification of the activity of some hormones related to the control of metabolic homeostasis. Finally, we recognize possible advantages of metabolic management of immunity to develop new strategies for treatment, diagnosis, and prevention of tuberculosis.

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