Synthesis of the nonproteinogenic amino acid (2S,3S,4S)-3-hydroxy-4-methylproline, a constituent of echinocandins

被引：13
|
作者：
Langlois, N [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 08期
关键词：
D O I：
10.1016/S0957-4166(98)00112-8
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An enantioselective synthesis of the unusual 3,4-disubstituted proline 2, a constituent of antifungal echinocandins, has been achieved through 1,3-dipolar cycloaddition of N-methylnitrone to the alpha,beta-unsaturated lactam 4 derived from (S)-pyroglutaminol. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：1333 / 1336
页数：4
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