Synthesis of the nonproteinogenic amino acid (2S,3S,4S)-3-hydroxy-4-methylproline, a constituent of echinocandins

被引：13

作者：

Langlois, N ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(98)00112-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enantioselective synthesis of the unusual 3,4-disubstituted proline 2, a constituent of antifungal echinocandins, has been achieved through 1,3-dipolar cycloaddition of N-methylnitrone to the alpha,beta-unsaturated lactam 4 derived from (S)-pyroglutaminol. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1333 / 1336

页数：4

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