High blood pressure in dementia: How low can we go?

被引：9

作者：

Turana, Yuda ^{[1
]}

Tengkawan, Jeslyn ^{[1
]}

Chia, Yook-Chin ^{[2
,3
]}

Teo, Boon Wee ^{[4
,5
]}

Shin, Jinho ^{[6
]}

Sogunuru, Guru Prasad ^{[7
,8
]}

Soenarta, Arieska Ann ^{[9
]}

Huynh Van Minh ^{[10
]}

Buranakitjaroen, Peera ^{[11
]}

Chen, Chen-Huan ^{[12
]}

Nailes, Jennifer ^{[13
]}

Hoshide, Satoshi ^{[14
]}

Park, Sungha ^{[15
]}

Siddique, Saulat ^{[16
]}

Sison, Jorge ^{[17
]}

Sukonthasarn, Apichard ^{[18
]}

Tay, Jam Chin ^{[19
]}

Wang, Tzung-Dau ^{[20
]}

Verma, Narsingh ^{[21
]}

Zhang, Yu-Qing ^{[22
,23
]}

Wang, Ji-Guang ^{[24
]}

Kario, Kazuomi ^{[14
]}

机构：

[1] Atma Jaya Catholic Univ Indonesia, Fac Med & Hlth Sci, Jakarta, Indonesia

[2] Sunway Univ, Sch Healthcare & Med Sci, Dept Med Sci, Bandar Sunway, Malaysia

[3] Univ Malaya, Dept Primary Care Med, Fac Med, Kuala Lumpur, Malaysia

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Div Nephrol, Dept Med, Singapore, Singapore

[5] Natl Univ Hlth Syst, Div Nephrol, Dept Med, Singapore, Singapore

[6] Hanyang Univ, Fac Cardiol Serv, Med Ctr, Seoul, South Korea

[7] MIOT Int Hosp, Chennai, Tamil Nadu, India

[8] Kathmandu Univ, Coll Med Sci, Bharatpur, Nepal

[9] Univ Indonesia, Natl Cardiovasc Ctr, Fac Med, Dept Cardiol & Vasc Med, Jakarta, Indonesia

[10] Hue Univ, Hue Univ Hosp, Dept Cardiol, Hue City, Vietnam

[11] Mahidol Univ, Fac Med, Dept Med, Siriraj Hosp, Bangkok, Thailand

[12] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei, Taiwan

[13] Univ East Ramon Magsaysay Mem Med Ctr Inc, Quezon City, Philippines

[14] Jichi Med Univ, Sch Med, Dept Med, Div Cardiovasc Med, Shimotsuke, Tochigi, Japan

[15] Yonsei Hlth Syst, Cardiovasc Hosp, Div Cardiol, Seoul, South Korea

[16] Fatima Mem Hosp, Lahore, Pakistan

[17] Med Ctr Manila, Dept Med, Sect Cardiol, Manila, Philippines

[18] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Cardiol, Chiang Mai, Thailand

[19] Tan Tock Seng Hosp, Dept Gen Med, Singapore, Singapore

[20] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan

[21] King Georges Med Univ, Dept Physiol, Lucknow, Uttar Pradesh, India

[22] Chinese Acad Med Sci & Peking Union Med Coll, Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China

[23] Chinese Acad Med Sci & Peking Union Med Coll, Fu Wai Hosp, Div Heart Failure, Beijing, Peoples R China

[24] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens,Ruijin Hosp,Shanghai Key, Dept Hypertens,Ctr Epidemiol Studies & Clin Trial, Shanghai, Peoples R China

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2020年 / 22卷 / 03期

关键词：

Asia; cognitive dysfunction; dementia; hypertension; oldest old; VASCULAR RISK-FACTORS; COGNITIVE FUNCTION; SYSTOLIC HYPERTENSION; INCIDENT DEMENTIA; ELDERLY-PATIENTS; DOUBLE-BLIND; ATHEROSCLEROSIS RISK; MIDLIFE; ASSOCIATION; VARIABILITY;

D O I：

10.1111/jch.13752

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertension is an important public health concern. The prevalence keeps increasing, and it is a risk factor for several adverse health outcomes including a decline in cognitive function. Recent data also show that the prevalence of hypertension and age-related dementia is rising in Asian countries, including in the oldest old group. This study aims to discuss possible treatments for high blood pressure in the elderly and propose an optimal target for BP relative to cognitive outcomes. This review discusses several studies on related blood pressure treatments that remain controversial and the consequences if the treatment target is too low or aggressive. Longitudinal, cross-sectional, and RCT studies were included in this review. An optimum systolic blood pressure of 120-130 mm Hg is recommended, especially in nondiabetic hypertensive patients with significant risk factors. In the oldest old group of patients, hypertension might have a protective effect. The use of calcium channel blockers (CCB) and angiotensin receptor blocker (ARB) is independently associated with a decreased risk of dementia in older people. However, personalized care for patients with hypertension, especially for patients who are frail or very old, is encouraged.

引用

页码：415 / 422

页数：8

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