Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells

被引：25

作者：

Gao, Chunpeng ^{[1
]}

Zhong, Laifu ^{[2
]}

Jiang, Liping ^{[2
]}

Geng, Chengyan ^{[2
]}

Yao, Xiaofeng ^{[1
]}

Cao, Jun ^{[1
]}

机构：

[1] Dalian Med Univ, Occupat & Environm Hlth Dept, Dalian 116044, Peoples R China

[2] Dalian Med Univ, China Japanese Joint Inst Med & Pharmaceut Sci, Dalian 116044, Peoples R China

来源：

PHYTOMEDICINE | 2013年 / 20卷 / 8-9期

基金：

中国国家自然科学基金;

关键词：

Phellinus linteus mushroom; Polysaccharides/glycoproteins; Mitochondrial impairment; Oxidative stress; mtDNA damage; GERMINATED BROWN RICE; HEPATOMA G2 CELLS; DNA DAMAGE; TUMOR-GROWTH; LIVER; ANTIOXIDANT; APOPTOSIS; LINK;

D O I：

10.1016/j.phymed.2013.02.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use. The intracellular mechanisms have not yet been elucidated. Phellinus linteus (PL) is a mushroom that has long been used as a folk medicine. In our previous study, we found that PL could decrease the reactive oxygen species (ROS) formation in HepG2 cells. Presently, protective effects of PL on tacrine-induced ROS formation and mitochondria dysfunction were evaluated. The results showed that PL significantly reduced tacrine-induced ROS production, disruption of Delta psi m, 8-OHdG formation in mitochondrial DNA, and cytotoxicity in HepG2 cells. These data suggest that PL could attenuate the cytotoxicity and mitochondria dysfunction induced by tacrine in HepG2 cells. The protection is probably mediated by an antioxidant protective mechanism. Consumption of PL may be a plausible way to prevent tacrine-induced hepatotoxicity. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：705 / 709

页数：5

共 27 条

[1]

[Anonymous], 1989, MUSHROOM SCI

[2] Mitochondrial abnonnalities - A link to idiosyncratic drug hepatotoxicity? [J].

Boelsterli, Urs A. ;

Lim, Priscilla L. K. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 220 (01) :92-107

[3] Curcumin Attenuates Acrylamide-induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging [J].

Cao, Jun ;

Liu, Yong ;

Jia, Li ;

Jiang, Li-Ping ;

Geng, Cheng-Yan ;

Yao, Xiao-Feng ;

Kong, Ying ;

Jiang, Bao-Na ;

Zhong, Lai-Fu .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (24) :12059-12063

[4] Curcurnin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells [J].

Cao, Jun ;

Liu, Yong ;

Jia, Li ;

Zhou, Hui-Min ;

Kong, Ying ;

Yang, Guang ;

Jiang, Li-Ping ;

Li, Qiu-Juan ;

Zhong, Lai-Fu .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 43 (06) :968-975

[5] Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells [J].

Cao, Jun ;

Jia, Li ;

Zhou, Hui-Min ;

Liu, Yong ;

Zhong, Lai-Fu .

TOXICOLOGICAL SCIENCES, 2006, 91 (02) :476-483

[6] Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells.: Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment [J].

Ezoulin, M. J. M. ;

Dong, C. Z. ;

Liu, Z. ;

Li, J. ;

Chen, H. Z. ;

Heymans, F. ;

Lelievre, L. ;

Ombetta, J. E. ;

Massicot, F. .

TOXICOLOGY IN VITRO, 2006, 20 (06) :824-831

[7] The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis [J].

Han, SB ;

Lee, CW ;

Jeon, YJ ;

Hong, ND ;

Yoo, ID ;

Yang, KH ;

Kim, HM .

IMMUNOPHARMACOLOGY, 1999, 41 (02) :157-164

[8] AGE-ASSOCIATED OXYGEN DAMAGE AND MUTATIONS IN MITOCHONDRIAL-DNA IN HUMAN HEARTS [J].

HAYAKAWA, M ;

HATTORI, K ;

SUGIYAMA, S ;

OZAWA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 189 (02) :979-985

[9] Mitochondrial and Immunoallergic Injury Increase Risk of Positive Drug Rechallenge After Drug-Induced Liver Injury: A Systematic Review [J].

Hunt, Christine M. .

HEPATOLOGY, 2010, 52 (06) :2216-2222

[10] Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats [J].

Jeon, TI ;

Hwang, SG ;

Lim, BO ;

Park, DK .

BIOTECHNOLOGY LETTERS, 2003, 25 (24) :2093-2096

← 1 2 3 →