Self-healing PEG-poly(aspartic acid) hydrogel with rapid shape recovery and drug release

被引：41
作者：
An, Heng [1 ]
Zhu, Linmiao [2 ]
Shen, Jiafu [1 ]
Li, Wenjuan [2 ,3 ]
Wang, Yong [2 ,3 ]
Qin, Jianglei [1 ,3 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
[2] Hebei Univ, Med Coll, Baoding 071002, Peoples R China
[3] Hebei Univ, Key Lab Pathogenesis Mech & Control Inflammatory, Baoding 071002, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2020年 / 185卷
关键词：
Self-healing; Hydrogel; Poly(aspartic acid); Dynamic chemical bond; Bio-degradability; COVALENT POLYMER NETWORKS; DYNAMIC BORONIC ESTER; HEALABLE HYDROGELS; PH; DELIVERY; GELS; RESPONSIVENESS; GLUCOSE;
D O I：
10.1016/j.colsurfb.2019.110601
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Self-healing hydrogels were prepared from hydrazide functionalized poly(aspartic acid) (PAsp). The polymer succinimide (PSI) was reacted with hydrazine and ethanolamine successively to obtain water soluble poly(aspartic acid) derivatives with hydrazide functional groups (PAEH). The hydrogel was prepared by cross-linking PAEH with poly(ethylene glycol) dialdehyde (PEG DA) under mild conditions without addition of catalyst. The rheological property and the self-healing property of the hydrogels were investigated intensively. The in vitro toxicity experiment showed the hydrogels have good bio-compatibility and the doxorubicin (DOX)-loaded hydrogels showed controlled release profile. Importantly, the hydrogel can still be degraded based on poly(aspartic acid) backbone. The bio-degradable poly(amino acid) based on self-healing hydrogel could have great potential application in bioscience including tissue repairing, drug loading and release.
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页数：7
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