Successful unrelated bone marrow transplantation in a child with chronic granulomatous disease complicated by pulmonary and cerebral granuloma formation

被引：17

作者：

Schuetz, Catharina

Hoenig, Manfred

Schulz, Ansgar

Lee-Kirsch, Min Ae

Roesler, Joachim

Friedrich, Wilhelm

von Bernuth, Horst

机构：

[1] Univ Ulm, Dept Pediat, D-89073 Ulm, Germany

[2] Tech Univ Dresden, Dept Pediat, D-8027 Dresden, Germany

[3] Univ Paris 05, INSERM, U 550, Lab Human Genet Infect Dis, F-75015 Paris, France

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2007年 / 166卷 / 08期

关键词：

chronic granulomatous disease; granuloma formation; cerebral lesions; bone marrow transplantation; APOPTOSIS; CGD; NEUTROPHILS;

D O I：

10.1007/s00431-006-0317-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report on a 6- year- old boy with chronic granulomatous disease ( CGD) complicated by chronic inflammatory reactions with formation of large pulmonary granuloma as well as intracerebral lesions. Bone marrow transplantation ( BMT) from an unrelated donor led to stable reconstitution, to rapid resolution of pulmonary granuloma, and to rapid resolution of intracerebral lesions.

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收藏

页码：785 / 788

页数：4

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