Immunodeficiency in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

被引：16
作者：
Xie, Sheling [1 ]
Wang, Kaifei [1 ]
Zhang, Wei [1 ]
Xiao, Kun [1 ]
Yan, Peng [1 ]
Li, Yanqin [1 ]
He, Wanxue [1 ]
Zhang, Yuhan [2 ]
Xie, Lixin [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, 28th Fuxing Rd, Beijing 100853, Peoples R China
[2] Nankai Univ, Sch Med, 94 Weijin Rd, Tianjin 300071, Peoples R China
来源：
INFLAMMATION | 2018年 / 41卷 / 05期
关键词：
chronic obstructive pulmonary disease; acute exacerbation of chronic obstructive pulmonary disease; immune deficiency; innate immunity; adaptive immunity; immunodeficiency; inflammation; CD8(+) T-CELLS; MACROPHAGE ACTIVATION; ALVEOLAR MACROPHAGES; PERIPHERAL-BLOOD; AIRWAY INFLAMMATION; CHRONIC-BRONCHITIS; LYMPHOCYTE RATIO; VIRAL-INFECTION; COPD; DIFFERENTIATION;
D O I：
10.1007/s10753-018-0830-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute exacerbation is infection. Immune deficiency, which induces dysfunction of anti-infection, plays an important role in the pathogenesis of acute exacerbation. As described in this review, the immune dysfunction in patients with AECOPD can be a major focus of efforts to therapeutic strategy.
引用
收藏
页码：1582 / 1589
页数：8
相关论文
共 83 条
[1]   Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease [J].
Abe, Y ;
Murphy, TF ;
Sethi, S ;
Faden, HS ;
Dmochowski, J ;
Harabuchi, Y ;
Thanavala, YM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (07) :967-971
[2]   Systemic signs of neutrophil mobilization during clinically stable periods and during exacerbations in smokers with obstructive pulmonary disease [J].
Andelid, Kristina ;
Andersson, Anders ;
Yoshihara, Shigemi ;
Ahren, Christina ;
Jirholt, Pernilla ;
Ekberg-Jansson, Ann ;
Linden, Anders .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2015, 10 :1253-1263
[3]   Chronic Obstructive Pulmonary Disease Th1 Cells Display Impaired Response to Endotoxin [J].
Bengoechea, Jose A. ;
Ito, Kazuhiro .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (02) :148-150
[4]   Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease [J].
Berenson, Charles S. ;
Kruzel, Ragina L. ;
Eberhardt, Ellana ;
Sethi, Sanjay .
JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (12) :2036-2045
[5]   Immune Dysfunction in Patients with Chronic Obstructive Pulmonary Disease [J].
Bhat, Tariq A. ;
Panzica, Louis ;
Kalathil, Suresh Gopi ;
Thanavala, Yasmin .
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2015, 12 :S169-S175
[6]   Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations [J].
Bhowmik, A ;
Seemungal, TAR ;
Sapsford, RJ ;
Wedzicha, JA .
THORAX, 2000, 55 (02) :114-120
[7]   Macrophage Heterogeneity in Respiratory Diseases [J].
Boorsma, Carian E. ;
Draijer, Christina ;
Melgert, Barbro N. .
MEDIATORS OF INFLAMMATION, 2013, 2013
[8]   COPD immunopathology [J].
Caramori, Gaetano ;
Casolari, Paolo ;
Barczyk, Adam ;
Durham, Andrew L. ;
Di Stefano, Antonino ;
Adcock, Ian .
SEMINARS IN IMMUNOPATHOLOGY, 2016, 38 (04) :497-515
[9]   Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease [J].
Chen, Long ;
Chen, Gang ;
Zhang, Ming-Qiang ;
Xiong, Xian-Zhi ;
Liu, Hong-Ju ;
Xin, Jian-Bao ;
Zhang, Jian-Chu ;
Wu, Jiang-Hua ;
Meng, Zhao-Ji ;
Sun, Sheng-Wen .
PEERJ, 2016, 4
[10]   Transcriptional Regulatory Networks for CD4 T Cell Differentiation [J].
Christie, Darah ;
Zhu, Jinfang .
TRANSCRIPTIONAL CONTROL OF LINEAGE DIFFERENTIATION IN IMMUNE CELLS, 2014, 381 :125-172
123456789