Increased Oxidative Stress in Patients with Pseudoexfoliation Syndrome

被引：17

作者：

Cumurcu, Tongabay ^{[1
]}

Gunduz, Abuzer ^{[4
]}

Ozyurt, Huseyin ^{[2
]}

Nurcin, Hatun ^{[1
]}

Atis, Omer ^{[2
]}

Egri, Mucahit ^{[3
]}

机构：

[1] Gaziosmanpasa Univ, Sch Med, Dept Ophthalmol, TR-60100 Tokat, Turkey

[2] Gaziosmanpasa Univ, Sch Med, Dept Biochem, TR-60100 Tokat, Turkey

[3] Gaziosmanpasa Univ, Sch Med, Dept Publ Hlth, TR-60100 Tokat, Turkey

[4] Hasan Calik State Hosp, Eye Clin, Malatya, Turkey

来源：

OPHTHALMIC RESEARCH | 2010年 / 43卷 / 04期

关键词：

Oxidative stress; Pseudoexfoliation syndrome; Total antioxidant capacity; TOTAL ANTIOXIDANT CAPACITY; PROTECTION; ACID;

D O I：

10.1159/000272019

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The objective of this study was to investigate the antioxidant/oxidant status of serum in patients with pseudoexfoliation syndrome (PEX). Methods: Forty-seven patients with PEX and 32 healthy controls were included in the study. Serum total antioxidant capacity (TAC) and total oxidant status (TOS) levels were determined by using a novel automated method. Results: A significant increase in serum TOS (p < 0.001) and a significant decrease in serum TAC (p < 0.0001) were observed in PEX patients compared to control subjects. Conclusion: TAC decreases while the oxidative stress increases in PEX. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：169 / 172

页数：4

共 24 条

[1] Antioxidant activity and constituents of propolis collected in various areas of Korea [J].

Ahn, MR ;

Kumazawa, S ;

Hamasaka, T ;

Bang, KS ;

Nakayama, T .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (24) :7286-7292

[2] Decreased total antioxidant capacity and increased oxidative stress in passive smoker infants and their mothers [J].

Aycicek, A ;

Erel, O ;

Kocyigit, A .

PEDIATRICS INTERNATIONAL, 2005, 47 (06) :635-639

[3] Total antioxidant capacity [J].

Bartosz, G .

ADVANCES IN CLINICAL CHEMISTRY, VOL 37, 2003, 37 :219-292

[4] A novel automated method to measure total antioxidant response against potent free radical reactions [J].

Erel, O .

CLINICAL BIOCHEMISTRY, 2004, 37 (02) :112-119

[5] A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation [J].

Erel, O .

CLINICAL BIOCHEMISTRY, 2004, 37 (04) :277-285

[6] A new automated colorimetric method for measuring total oxidant status [J].

Erel, O .

CLINICAL BIOCHEMISTRY, 2005, 38 (12) :1103-1111

[7] Glutathione and lipid peroxide changes in pseudoexfoliation syndrome [J].

Gartaganis, SP ;

Georgakopoulos, CD ;

Patsoukis, NE ;

Gotsis, SS ;

Gartaganis, VS ;

Georgiou, CD .

CURRENT EYE RESEARCH, 2005, 30 (08) :647-651

[8]

HU ML, 1993, J LAB CLIN MED, V121, P257

[9] Decreased total antioxidant response and increased oxidative stress in Behcet's disease [J].

Isik, Ahmet ;

Koca, Suleynian Serdar ;

Ustundag, Bilal ;

Selek, Sahabettin .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 212 (02) :133-141

[10] 8-isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome [J].

Koliakos, GG ;

Konstas, AGP ;

Schlötzer-Schrehardt, U ;

Hollo, G ;

Katsimbris, IE ;

Georgiadis, N ;

Ritch, R .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2003, 87 (03) :353-356

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