Enantioselective Nitroso Aldol Reaction Catalyzed by QuinoxP*•Silver(I) Complex and Tin Methoxide

被引：61

作者：

Yanagisawa, Akira ^{[1
]}

Takeshita, Satoshi ^{[1
]}

Izumi, Youhei ^{[1
]}

Yoshida, Kazuhiro ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Sci, Dept Chem, Chiba 2638522, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 15期

关键词：

ASYMMETRIC ALPHA-AMINOXYLATION; ALDEHYDES; KETONES; 1,2-DIOLS; HYDROXY; LIGAND; RICH;

D O I：

10.1021/ja910588w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic enantioselective O-nitroso aldol reaction of alkenyl trichloroacetates with nitrosoarenes was achieved using the (R,R)-t-Bu-QuinoxP*center dot AgOAc complex as the chiral catalyst and Bu(2)Sn(OMe)(2) as the achiral cocatalyst in the presence of methanol. Optically active a-aminooxy ketones with up to 99% ee were regioselectively obtained in high yields from various alkenyl trichloroacetates of cyclic ketones.

引用

页码：5328 / +

页数：3

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