Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

被引：18
作者：
Khattab, R. R. [1 ]
Hassan, A. A. [2 ,3 ]
Kutkat, O. M. [4 ]
Abuzeid, K. M. [1 ]
Hassan, N. A. [1 ,3 ]
机构：
[1] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt
[2] Univ Suez, Fac Sci, Chem Dept, Suez, Egypt
[3] Shaqra Univ, Coll Pharm, Pharmaceut Sci Dept, Riyadh, Saudi Arabia
[4] Natl Res Ctr, Ctr Sci Excellence Influenza Virus, Cairo 12311, Egypt
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期
关键词：
triazolo derivatives; monosaccharides; sugar hydrazones; C-nucleosides; antiviral activity; BIOLOGICAL EVALUATION; DERIVATIVES; ANTICANCER; THIENOPYRIMIDINES;
D O I：
10.1134/S1070363219080267
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, H-1, and C-13 NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.
引用
收藏
页码：1707 / 1717
页数：11
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