Another Near Full-Length Sequence of an HIV-1 CRF01_AE/CRF07_BC Recombinant Virus from a Man Who Has Sex with Men in Tianjin, China

被引：0
作者：
Zhou, Zehua [1 ]
Ma, Ping [1 ]
Feng, Yi [2 ]
Ou, Weidong [2 ]
Shao, Yiming [2 ,3 ]
Wei, Min [1 ]
机构：
[1] Nankai Univ, Sch Med, Peoples Hosp 2, 94 Weijin Rd, Tianjin 300071, Peoples R China
[2] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China
[3] Nankai Univ, Sch Med, Tianjin, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2019年 / 35卷 / 09期
基金：
中国国家自然科学基金;
关键词：
HIV-1; URF; CRF; MSM; CIRCULATING RECOMBINANT; SUBTYPES;
D O I：
10.1089/aid.2019.0071
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Surprisingly, more new unique recombinant forms (URFs) of CRF01_AE/CRF07_BC recombinant viruses were found in Tianjin, China, recently. Here we identified another novel HIV-1 recombinant virus (TJ20170315) isolated from an HIV-1 positive man who has sex with men in Tianjin, China. Phylogenetic analysis of the near full-length genome of TJ20170315 showed that it formed a monophyletic branch within the cluster of CRF01_AE reference sequences. Recombinant analysis showed that the virus kept the CRF01_AE parental backbone, and one CRF07_BC segment was inserted into gag, pol genes of the CRF01_AE backbone. Nowadays, multiple kinds of circulating recombinant forms (CRFs) and URFs were identified among men who has sex with men in China. The emergency of URFs highlights the complexity of HIV-1 infection in Tianjin, China, and implies that the next new CRF and HIV-1 epidemic are coming on the road.
引用
收藏
页码：865 / 869
页数：5
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