Syntheses of bis(3′-indolyl)-2(1H)-pyrazinones

被引：32

作者：

Jiang, B ^{[1
]}

Gu, XH ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

HETEROCYCLES | 2000年 / 53卷 / 07期

关键词：

bisinoble alkaloid; dipeptidyl aldehyde; bisindolyl ketone amine; cyclization;

D O I：

10.3987/COM-00-8887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of 3,6-bis(3'-indolyl)-2(1H)-pyrazinone and 3,5-bis(3'-indolyl)-2( 1H)-pyrazinone were described. Syntheses of 3,6-bis(3 '-indolyl)2(1H)-pyrazinone proceeded through the condensation of N-Boc-indolylglycine with indol-3-yl-N-methyl-O-methoxyglycinamide, and followed by reduction with LiAlH4 and cyclization of the resulting bisindolyl aldehyde-amine. 3,5-Bis(3'-indolyl)-2(1H)-pyrazinone was synthesized by cyclization of bisindolyl ketone amine in excess of ammonia under pressure.

引用

页码：1559 / 1568

页数：10

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