RETRACTED: Two/zero-dimensional Cu(II) complexes inhibit atrial myxoma cells via apoptosis (Retracted article. See vol. 1275, 2023)

Two new Cu(II)-containing coordination complexes with the chemical formulae of [Cu-2(pydc)(2)(H2O)(2)] n (1, pydc = 3,5-pyridinedicarboxylate) and {[Cu(H2O)(2)(H(3)hmidc)(2)](H2O)}(n) (2, H(4)hmidc = 2-(hydrox-ymethyl)-1H-imidazole-4,5-dicarboxylic acid) have been successfully synthesized and characterized under solvothermal conditions. The in vitro anti-tumor activities of compounds 1 and 2 were studied on human atrial myxoma cell HemECs. The WST-8 assay indicated only the compound 1 showed high anticancer ability but not compound 2. And both the TUNEL staining and the Annexin V-FITC/PI assay confirmed that compound 1 induced cell death via apoptosis. Then, the further ROS assay revealed that the compound 1 could induce the HemECs cell apoptosis by increasing the generation of ROS. (C) 2019 Elsevier B.V. All rights reserved.