RETRACTED: Two/zero-dimensional Cu(II) complexes inhibit atrial myxoma cells via apoptosis (Retracted article. See vol. 1275, 2023)

被引：1
|
作者：
Tian, Yu-Ying [1 ]
Xin, Zhi-Guo [2 ]
Hou, Hai-Feng [3 ]
Zhu, Xiao-Chun [1 ]
Guo, Qian [4 ]
Xiao, Qin [5 ]
机构：
[1] Inner Mongolia Univ Nationalities, Affiliated Hosp, Dept Pathol, Tongliao 028000, Peoples R China
[2] Tongliao Hosp Inner Mongolia, Dept Cardiovasc Med, Tongliao 028000, Peoples R China
[3] Inner Mongolia Univ Nationalities, Affiliated Hosp, Dept Thorac Surg, Tongliao 028000, Peoples R China
[4] China Natl Petr & Nat Gas Corp, Cent Hosp, Dept Oncol, Langfang, Hebei, Peoples R China
[5] Inner Mongolia Univ Nationalities, Affiliated Hosp, Dept Ophthalmol, Tongliao 028000, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1198卷
关键词：
Coordination polymers; X-ray diffraction; Anti-cancer; Apoptosis; ROS; DNA CLEAVAGE; ANTICANCER;
D O I：
10.1016/j.molstruc.2019.126937
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Two new Cu(II)-containing coordination complexes with the chemical formulae of [Cu-2(pydc)(2)(H2O)(2)] n (1, pydc = 3,5-pyridinedicarboxylate) and {[Cu(H2O)(2)(H(3)hmidc)(2)](H2O)}(n) (2, H(4)hmidc = 2-(hydrox-ymethyl)-1H-imidazole-4,5-dicarboxylic acid) have been successfully synthesized and characterized under solvothermal conditions. The in vitro anti-tumor activities of compounds 1 and 2 were studied on human atrial myxoma cell HemECs. The WST-8 assay indicated only the compound 1 showed high anticancer ability but not compound 2. And both the TUNEL staining and the Annexin V-FITC/PI assay confirmed that compound 1 induced cell death via apoptosis. Then, the further ROS assay revealed that the compound 1 could induce the HemECs cell apoptosis by increasing the generation of ROS. (C) 2019 Elsevier B.V. All rights reserved.
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页数：7
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