Role of Interleukin-18 in Destabilization of the Atherosclerotic Plaque in Humans

被引：9

作者：

Pigarevskii, P. V. ^{[1
]}

Maltseva, S. V. ^{[1
]}

Snegova, V. A. ^{[1
]}

Davydova, N. G. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Expt Med, Dept Common & Special Morphol, North Western Div, St Petersburg P-22, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

unstable atherosclerotic plaque; interleukin-18; elastic and collagen fibers;

D O I：

10.1007/s10517-014-2675-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Precise location of IL-18 in cell and tissue elements of the atherosclerotic lesions in humans and its role in destabilization of the atherosclerotic plaque were detected. The data suggested a hypothesis on indirect involvement of IL-18 in destruction of the elastic and collagen fibers in an unstable plaque due to this cytokine capacity to induce the production of IFN-gamma in T cells and macrophages, this eventually leading to inhibition of collagen and elastin synthesis in smooth muscle cells of the vascular wall and to loosening of the plaque cap.

引用

页码：821 / 824

页数：4

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