At what speed does spinal degeneration gear up?: Aging Paradigm in patients with Low Back Pain

被引：17

作者：

Eksi, Murat Sakir ^{[1
]}

Orhun, Omer ^{[2
]}

Yasar, Ahmet Harun ^{[3
]}

Dursun, Ahmet Taha ^{[2
]}

Berikol, Gurkan ^{[4
]}

Borekci, Ali ^{[5
]}

Ozcan-Eksi, Emel Ece ^{[6
]}

机构：

[1] Yeditepe Univ, Sch Med, Neurosurg Res Lab, Istanbul, Turkey

[2] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Istanbul, Turkey

[3] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Neurosurg, Istanbul, Turkey

[4] Taksim Training & Res Hosp, Neurosurg Clin, Istanbul, Turkey

[5] FSM Training & Res Hosp, Neurosurg Clin, Istanbul, Turkey

[6] Bahcesehir Univ, Sch Med, Dept Phys Med & Rehabil, Istanbul, Turkey

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2022年 / 215卷

关键词：

Disc degeneration; End-plate; Modic changes; Aging; DISC DEGENERATION; LUMBAR SPINE; MODIC CHANGES; RISK-FACTORS; PREVALENCE; ASSOCIATION; AGE;

D O I：

10.1016/j.clineuro.2022.107187

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Aging is a cause of spinal degeneration. However, the natural history of degeneration process is unclear. We aimed to analyze change of intervertebral disc degeneration (IVDD) and Modic changes in Caucasians with LBP decade by decade. We also aimed to find out breaking points of having severe IVDD and Modic changes throughout human life. Patients and methods: We conducted a cross-sectional analysis of a retrospective database in patients aged between 10 and 100 years. All patients were evaluated in terms of IVDD and Modic changes. Optimal binning was conveyed to group age of the patients in terms of major changes in percentages of severe IVDD and Modic changes. Results: We evaluated 2434 patients (female: 1328 and male: 1106; mean age: 47.2 +/- 17.2 years; age range = 10-98 years). In all patients, 50.5% and 23.6% had severe IVDD and Modic changes at any lumbar level, respectively. Women were significantly more likely to have severe IVDD than men. Frequency of Modic changes at any lumbar level significantly increased in 40 s and 60 s, whereas frequency of severe IVDD at any lumbar level significantly increased in 20 s, 30 s, 50 s and 70 s Conclusion: Spinal degeneration had specific gear-up periods in human life. Age groups of future spine studies could be defined according to the new defined change periods of severe IVDD and Modic changes in human life.

引用

页数：8

共 43 条

[1] Physiological testosterone levels enhance chondrogenic extracellular matrix synthesis by male intervertebral disc cells in vitro, but not by mesenchymal stem cells [J].