Purification development of carrier-free 47Sc produced from natTi(n,p) reaction for radiotheranostic applications

被引：5

作者：

Gizawy, Mohamed A. ^{[1
]}

Shamsel-Din, Hesham A. ^{[1
]}

Attallah, M. F. ^{[2
]}

机构：

[1] Egyptian Atom Energy Author, Res Reactor ETRR2 & Labeled Cpds Dept 2, Hot Labs Ctr, Radioisotopes Prod Facil RPF, POB 13759, Cairo, Egypt

[2] Egyptian Atom Energy Author, Analyt Chem & Control Dept, Hot Labs Ctr, POB 13759, Cairo, Egypt

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2021年 / 328卷 / 03期

关键词：

Sc-47; Theranostics; Reactor produced radioisotopes; Natural titanium oxide (TiO2); Anionic exchanger (AN-31); AN-PAR; 4-(2-PYRIDYLAZO) RESORCINOL; SEPARATION; TITANIUM; COMPOSITE; THERAPY;

D O I：

10.1007/s10967-021-07745-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This work spotlights on the rapid and effective separation method for the no-carrier-added (NCA) Sc-47 from natural irradiated Ti target using an anionic exchanger resin; AN-31 impregnated with 4-(2-Pyridylazo) resorcinol (PAR). The newly prepared resin (An-PAR) was characterized by FTIR and SEM. The Influence of pH on the distribution coefficients (K-d) of Sc(III) and Ti(IV) ions was investigated by batch technique and the results revealed that Ti(IV) ions are strongly adsorbed by AN-PAR rather than AN-31, while Sc(III) ions are weakly adsorbed on the both resin materials. The radiochemical separation of Sc-47(III) from irradiated natural Ti target was successfully carried out, where the elution efficiency for Sc-47 reached 89 +/- 1.5% with high radiochemical, radionuclidic and chemical purities. Our findings thus hold a great promise for the use of Sc-47 radioisotope in the preparation of radiopharmaceuticals for theranostics applications.

引用

页码：1225 / 1230

页数：6

共 19 条

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