Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study

被引：17

作者：

De Cecio, Rossella ^{[1
]}

Cantile, Monica ^{[1
]}

Collina, Francesca ^{[1
]}

Marra, Laura ^{[1
]}

Santonastaso, Clemente ^{[1
]}

Scaffa, Cono ^{[2
]}

Botti, Gerardo ^{[1
]}

Losito, Nunzia Simona ^{[1
]}

机构：

[1] Ist Nazl Tumori Fdn G Pascale, Pathol Unit, I-80131 Naples, Italy

[2] Ist Nazl Tumori Fdn G Pascale, Dept Gynecol Oncol, I-80131 Naples, Italy

来源：

JOURNAL OF OVARIAN RESEARCH | 2014年 / 7卷

关键词：

Brenner tumors; Immuno-profile; Molecular analyses; GENETIC-ANALYSIS; PATHOGENESIS; ORIGIN;

D O I：

10.1186/s13048-014-0101-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Borderline Brenner tumor of the ovary is a rare entity characterized by papillary structures with a fibro-vascular core, covered by a transitional epithelium, and by the absence of stromal infiltration. It is associated, by definition, with a benign component of Brenner tumor. Case: We report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses.

引用

页数：5

共 9 条

[1]

Clement P.B., 2008, Atlas of Gynecologic Surgical Pathology

[2] Transitional Cell Tumors of the Ovary A Comparative Clinicopathologic, Immunohistochemical, and Molecular Genetic Analysis of Brenner Tumors and Transitional Cell Carcinomas [J].

Cuatrecasas, Miriam ;

Catasus, Luis ;

Palacios, Jose ;

Prat, Jaime .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (04) :556-567

[3] Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary [J].

Hermanns, B ;

Faridi, A ;

Rath, W ;

Füzesi, L ;

Schröder, W .

ULTRASTRUCTURAL PATHOLOGY, 2000, 24 (03) :191-196

[4] Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors [J].

Kondi-Pafiti, A. ;

Kairi-Vassilatou, Evi ;

Iavazzo, Ch. ;

Vouza, Em. ;

Mavrigiannaki, P. ;

Kleanthis, Ch. ;

Vlahodimitropoulos, D. ;

Liapis, A. .

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2012, 285 (06) :1699-1702

[5] The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis [J].

Kuhn, Elisabetta ;

Ayhan, Ayse ;

Shih, Ie-Ming ;

Seidman, Jeffrey D. ;

Kurman, Robert J. .

MODERN PATHOLOGY, 2014, 27 (02) :231-237

[6] Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium [J].

Kuhn, Elisabetta ;

Ayhan, Ayse ;

Shih, Ie-Ming ;

Seidman, Jeffrey D. ;

Kurman, Robert J. .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (18) :3839-3849

[7] Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer-Shifting the paradigm [J].

Kurman, Robert J. ;

Shih, Ie-Ming .

HUMAN PATHOLOGY, 2011, 42 (07) :918-931

[8]

Lee KR., 2003, WHO Classification of Tumours 2003, P117

[9] Management and Prognosis of Borderline Ovarian Brenner Tumors [J].

Uzan, Catherine ;

Dufeu-Lefebvre, Marion ;

Fauvet, Raffaele ;

Gouy, Sebastien ;

Duvillard, Pierre ;

Darai, Emile ;

Morice, Philippe .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2012, 22 (08) :1332-1336

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