Interleukin-5 Inhibitors for Severe Asthma: Rationale and Future Outlook

被引：22

作者：

Shrimanker, Rahul ^{[1
]}

Pavord, Ian D. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, NDM Res Bldg,Old Rd Campus, Oxford OX3 7FZ, England

来源：

BIODRUGS | 2017年 / 31卷 / 02期

关键词：

SEVERE EOSINOPHILIC ASTHMA; OBSTRUCTIVE PULMONARY-DISEASE; CELL-MEDIATED CYTOTOXICITY; ALPHA MONOCLONAL-ANTIBODY; PLACEBO-CONTROLLED TRIAL; CONTROLLED PHASE-3 TRIAL; AIRWAY HYPERRESPONSIVENESS; SPUTUM EOSINOPHILIA; CLUSTER-ANALYSIS; DOUBLE-BLIND;

D O I：

10.1007/s40259-017-0215-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this review, we outline the pathophysiology of severe asthma and discuss the role of anti-interleukin (IL)-5 inhibitors for the treatment of asthma. Anti-IL-5 treatments have shown efficacy in reducing the rate of severe asthma attacks in eosinophilic asthma. We review the history of the development of these agents, lessons learnt about severe asthma along the way and key clinical trials supporting efficacy of the three anti-IL-5 treatments that are clinically available or undergoing clinical trials in asthma.

引用

页码：93 / 103

页数：11

共 48 条

[41] The use of induced sputum to investigate airway inflammation [J].

Pavord, ID ;

Pizzichini, MMM ;

Pizzichini, E ;

Hargreave, FE .

THORAX, 1997, 52 (06) :498-501

[42] Eosinophils: changing perspectives in health and disease [J].

Rosenberg, Helene F. ;

Dyer, Kimberly D. ;

Foster, Paul S. .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (01) :9-22

[43] Tc2 cells respond to soluble antigen in the respiratory tract and induce lung eosinophilia and bronchial hyperresponsiveness [J].

Sawicka, E ;

Noble, A ;

Walker, C ;

Kemeny, DM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (09) :2599-2608

[44] Biomarkers in the Management of Difficult Asthma [J].

Schleich, Florence ;

Sophie, Demarche ;

Renaud, Louis .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (14) :1561-1573

[45] Eosinophils in innate immunity: an evolving story [J].

Shamri, Revital ;

Xenakis, Jason J. ;

Spencer, Lisa A. .

CELL AND TISSUE RESEARCH, 2011, 343 (01) :57-83

[46] Inflammatory subtypes in asthma: Assessment and identification using induced sputum [J].

Simpson, JL ;

Scott, R ;

Boyle, MJ ;

Gibson, PG .

RESPIROLOGY, 2006, 11 (01) :54-61

[47] Interleukin-5 and IL-5 receptor in health and diseases [J].

Takatsu, Kiyoshi .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2011, 87 (08) :463-485

[48] Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy [J].

Van Gool, Frederic ;

Molofsky, Ari B. ;

Morar, Malika M. ;

Rosenzwajg, Michelle ;

Liang, Hong-Erh ;

Klatzmann, David ;

Locksley, Richard M. ;

Bluestone, Jeffrey A. .

BLOOD, 2014, 124 (24) :3572-3576

← 1 2 3 4 5 →