Interleukin-5 Inhibitors for Severe Asthma: Rationale and Future Outlook

被引：22

作者：

Shrimanker, Rahul ^{[1
]}

Pavord, Ian D. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, NDM Res Bldg,Old Rd Campus, Oxford OX3 7FZ, England

来源：

BIODRUGS | 2017年 / 31卷 / 02期

关键词：

SEVERE EOSINOPHILIC ASTHMA; OBSTRUCTIVE PULMONARY-DISEASE; CELL-MEDIATED CYTOTOXICITY; ALPHA MONOCLONAL-ANTIBODY; PLACEBO-CONTROLLED TRIAL; CONTROLLED PHASE-3 TRIAL; AIRWAY HYPERRESPONSIVENESS; SPUTUM EOSINOPHILIA; CLUSTER-ANALYSIS; DOUBLE-BLIND;

D O I：

10.1007/s40259-017-0215-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this review, we outline the pathophysiology of severe asthma and discuss the role of anti-interleukin (IL)-5 inhibitors for the treatment of asthma. Anti-IL-5 treatments have shown efficacy in reducing the rate of severe asthma attacks in eosinophilic asthma. We review the history of the development of these agents, lessons learnt about severe asthma along the way and key clinical trials supporting efficacy of the three anti-IL-5 treatments that are clinically available or undergoing clinical trials in asthma.

引用

页码：93 / 103

页数：11

共 48 条

[1] Therapeutic Strategies for Harnessing Human Eosinophils in Allergic Inflammation, Hypereosinophilic Disorders, and Cancer [J].

Amini-Vaughan, Zhaleh J. ;

Martinez-Moczygemba, Margarita ;

Huston, David P. .

CURRENT ALLERGY AND ASTHMA REPORTS, 2012, 12 (05) :402-412

[2] Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial [J].

Bafadhel, Mona ;

McKenna, Susan ;

Terry, Sarah ;

Mistry, Vijay ;

Pancholi, Mitesh ;

Venge, Per ;

Lomas, David A. ;

Barer, Michael R. ;

Johnston, Sebastian L. ;

Pavord, Ian D. ;

Brightling, Christopher E. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :48-55

[3] Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma [J].

Bel, Elisabeth H. ;

Wenzel, Sally E. ;

Thompson, Philip J. ;

Prazma, Charlene M. ;

Keene, Oliver N. ;

Yancey, Steven W. ;

Ortega, Hector G. ;

Pavord, Ian D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (13) :1189-1197

[4] Rationale and Clinical Results of Inhibiting Interleukin-5 for the Treatment of Severe Asthma [J].

Berair, Rachid ;

Pavord, Ian D. .

CURRENT ALLERGY AND ASTHMA REPORTS, 2013, 13 (05) :469-476

[5] Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels A Randomized Phase 3 Study [J].

Bjermer, Leif ;

Lemiere, Catherine ;

Maspero, Jorge ;

Weiss, Sivan ;

Zangrilli, James ;

Germinaro, Matthew .

CHEST, 2016, 150 (04) :789-798

[6] Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial [J].

Bleecker, Eugene R. ;

FitzGerald, J. Mark ;

Chanez, Pascal ;

Papi, Alberto ;

Weinstein, Steven F. ;

Barker, Peter ;

Sproule, Stephanie ;

Gilmartin, Geoffrey ;

Aurivillius, Magnus ;

Werkstrom, Viktoria ;

Goldman, Mitchell .

LANCET, 2016, 388 (10056) :2115-2127

[7] Targeting cytokines in asthma therapy: round one [J].

Boushey, HA ;

Fahy, JV .

LANCET, 2000, 356 (9248) :2114-2116

[8] EOSINOPHILIC INFLAMMATION IN ASTHMA [J].

BOUSQUET, J ;

CHANEZ, P ;

LACOSTE, JY ;

BARNEON, G ;

GHAVANIAN, N ;

ENANDER, I ;

VENGE, P ;

AHLSTEDT, S ;

SIMONYLAFONTAINE, J ;

GODARD, P ;

MICHEL, FB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1033-1039

[9] Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial [J].

Brightling, CE ;

Monteiro, W ;

Ward, R ;

Parker, D ;

Morgan, MDL ;

Wardlaw, AJ ;

Pavord, ID .

LANCET, 2000, 356 (9240) :1480-1485

[10] Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase I study of subjects with mild asthma [J].

Busse, William W. ;

Katial, Rohit ;

Gossage, David ;

Sari, Suha ;

Wang, Bing ;

Kolbeck, Roland ;

Coyle, Anthony J. ;

Koike, Masamichi ;

Spitalny, George L. ;

Kiener, Peter A. ;

Geba, Gregory P. ;

Molfino, Nestor A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (06) :1237-1244

← 1 2 3 4 5 →