COMPARISON OF ORGANOCHLORINE PESTICIDE LEVELS BETWEEN HUMAN BLOOD SERUM AND ADIPOSE TISSUE

被引：0

作者：

Del Carmen Martinez-Valenzuela, Maria ^{[1
]}

Waliszewski, Stefan M. ^{[2
]}

Gomez-Arroyo, Sandra ^{[3
]}

Villalobos-Pietrini, Rafael ^{[3
]}

Calderon-Vazquez, Carlos ^{[4
]}

Ortega-Martinez, Daniel ^{[5
]}

Meza, Enrique ^{[2
]}

Caba, Mario ^{[2
]}

机构：

[1] Univ Occidente, Inst Invest Ambiente & Salud, Bulevar Macario Gaxiola & Carretera Int, Los Mochis 81223, Sinaloa, Mexico

[2] Univ Veracruzana, Ctr Invest Biomed, Xalapa 91190, Veracruz, Mexico

[3] Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Ciudad Univ, Ciudad De Mexico 04510, DF, Mexico

[4] Inst Politecn Nacl, Unidad Sinaloa, Ctr Interdisciplinario Invest Desarrollo Integral, Bulevar Juan de Dios Batiz Paredes 250, Guasave 81101, Sinaloa, Mexico

[5] Univ Popular Autonoma Estado Puebla, Dept Ciencias Biol, 13 Poniente 1927, Puebla 72410, Mexico

来源：

REVISTA INTERNACIONAL DE CONTAMINACION AMBIENTAL | 2017年 / 33卷 / 03期

关键词：

plasma; fat tissue; toxicokinetic; biological matrices; MEXICO; INHABITANTS; VERACRUZ; BIOCONCENTRATION; SAMPLES; PUEBLA; LIPIDS;

D O I：

10.20937/RICA.2017.33.03.03

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The organochlorine pesticides, being lipophilic compounds, show extremely high thermodynamic stability and resistance to degradation processes in the environment and in living organisms. They accumulate in lipid rich tissues and distribute between transport compartment (blood) and store compartment (adipose tissue). The purpose of this study is to make a comparison between organochlorine pesticide levels in blood serum and adipose tissue and calculate the differences in their concentrations based on routine biomonitoring study. One hundred and twenty six pair samples of adipose tissue and blood serum during autopsies as a case study were taken and analyzed in Los Mochis Sinaloa, Mexico. Among organochlorine pesticides, higher concentrations correspond to b-HCH, pp'DDE and op'DDT in blood serum lipids; and pp'DDT shows higher concentrations in adipose tissue. Using statistical comparisons, we found a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue. This concludes that serum lipid organochlorine pesticide concentrations represent an important indicator for both human biological matrices.

引用

页码：393 / 401

页数：9

共 24 条

[1] Organochlorine pesticides and PCBs in air of southern Mexico (2002-2004) [J].

Alegria, Henry A. ;

Wong, Fiona ;

Jantunen, Liisa M. ;

Bidleman, Terry F. ;

Salvador Figueroa, Miguel ;

Gold Bouchot, Gerardo ;

Ceja Moreno, Victor ;

Waliszewski, Stefan M. ;

Infanzon, Raul .

ATMOSPHERIC ENVIRONMENT, 2008, 42 (38) :8810-8818

[2]

[Anonymous], 2003, POL BIPH HUM HLTH AS

[3] Inverse correlation among organochlorine pesticide levels to total lipid serum contents: a preliminary study in Veracruz, Mexico [J].

Caba, Mario ;

Meza, Enrique ;

Waliszewski, Stefan M. ;

Martinez-Valenzuela, Carmen .

ENVIRONMENTAL MONITORING AND ASSESSMENT, 2015, 187 (07)

[4] Quantitative interpretation of human biomonitoring data [J].

Clewell, Harvey J. ;

Tan, Yu Mei ;

Campbell, Jerry L. ;

Andersen, Melvin E. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 231 (01) :122-133

[5] Changes in persistent organic pollutant levels from adolescence to young adulthood [J].

Gallo, Mia V. ;

Deane, Glenn D. ;

DeCaprio, Anthony P. ;

Schell, Lawrence M. .

ENVIRONMENTAL RESEARCH, 2015, 140 :214-224

[6] Elimination half-lives of polychlorinated biphenyl congeners in children [J].

Grandjean, Philippe ;

Budtz-Jorgensen, Esben ;

Barr, Dana B. ;

Needham, Larry L. ;

Weihe, Pal ;

Heinzow, Birger .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (18) :6991-6996

[7] Organochlorine Pesticide Gradient Levels Among Maternal Adipose Tissue, Maternal Blood Serum and Umbilical Blood Serum [J].

Herrero-Mercado, Margarita ;

Waliszewski, S. M. ;

Caba, M. ;

Martinez-Valenzuela, C. ;

Arroyo, S. Gomez ;

Villalobos Pietrini, R. ;

Cantu Martinez, P. C. ;

Hernandez-Chalate, F. .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2011, 86 (03) :289-293

[8] Temporal changes in PCB and DDE levels among a cohort of frequent and infrequent consumers of Great Lakes sportfish [J].

Knobeloch, Lynda ;

Turyk, Mary ;

Imm, Pamela ;

Schrank, Candy ;

Anderson, Henry .

ENVIRONMENTAL RESEARCH, 2009, 109 (01) :66-72

[9] Persistent organochlorine and organobromine compounds in mother's milk from Sweden 1996-2006: Compound-specific temporal trends [J].

Lignell, Sanna ;

Aune, Marie ;

Darnerud, Per Ola ;

Cnattingius, Sven ;

Glynn, Anders .

ENVIRONMENTAL RESEARCH, 2009, 109 (06) :760-767

[10] Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: A causal framework for the association with K-ras mutations in pancreatic cancer [J].

Lopez, Tomas ;

Pumarega, Jose A. ;

Pollack, Anna Z. ;

Lee, Duk-Hee ;

Richiardi, Lorenzo ;

Jacobs, David R., Jr. ;

Schisterman, Enrique F. ;

Porta, Miguel .

CHEMOSPHERE, 2014, 114 :219-225

← 1 2 3 →