Molecular pathways controlling barrier function in IBD

被引：83

作者：

Atreya, Raja ^{[1
]}

Neurath, Markus F. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Med 1, D-91054 Erlangen, Germany

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2015年 / 12卷 / 02期

关键词：

T-CELLS; EPITHELIUM; COLITIS;

D O I：

10.1038/nrgastro.2014.201

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Several key studies published in 2014 have shed light on the pathogenesis of IBD by investigating the molecular mechanisms controlling mucosal homeostasis and intestinal barrier function. These studies revealed that alterations of intestinal homeostasis drive chronic intestinal inflammation. Here, we describe these findings and discuss future directions for translational research in IBD.

引用

页码：67 / 68

页数：2

共 10 条

[1]

Chassaing B., Gastroenterology

[2] T helper cell 1-type CD4(+) T cells, but not B cells, mediate colitis in interleukin 10-deficient mice [J].

Davidson, NJ ;

Leach, MW ;

Fort, MM ;

ThompsonSnipes, L ;

Kuhn, R ;

Muller, W ;

Berg, DJ ;

Rennick, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (01) :241-251

[3] Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis [J].

Fuss, IJ ;

Heller, F ;

Boirivant, M ;

Leon, F ;

Yoshida, M ;

Fichtner-Feigl, S ;

Yang, ZQ ;

Exley, M ;

Kitani, A ;

Blumberg, RS ;

Mannon, P ;

Strober, W .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (10) :1490-1497

[4] TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells [J].

Gerlach, Katharina ;

Hwang, YouYi ;

Nikolaev, Alexej ;

Atreya, Raja ;

Dornhoff, Heike ;

Steiner, Stefanie ;

Lehr, Hans-Anton ;

Wirtz, Stefan ;

Vieth, Michael ;

Waisinan, Ari ;

Rosenbauer, Frank ;

McKenzie, Andrew N. J. ;

Weigmann, Benno ;

Neurath, Markus F. .

NATURE IMMUNOLOGY, 2014, 15 (07) :676-686

[5] Ex vivo culture of the intestinal epithelium: strategies and applications [J].

Leushacke, Marc ;

Barker, Nick .

GUT, 2014, 63 (08) :1345-1354

[6] Cytokines in inflammatory bowel disease [J].

Neurath, Markus F. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (05) :329-342

[7] Protective mucosal immunity mediated by epithelial CD1d and IL-10 [J].

Olszak, Torsten ;

Neves, Joana F. ;

Dowds, C. Marie ;

Baker, Kristi ;

Glickman, Jonathan ;

Davidson, Nicholas O. ;

Lin, Chyuan-Sheng ;

Jobin, Christian ;

Brand, Stephan ;

Sotlar, Karl ;

Wada, Koichiro ;

Katayama, Kazufumi ;

Nakajima, Atsushi ;

Mizuguchi, Hiroyuki ;

Kawasaki, Kunito ;

Nagata, Kazuhiro ;

Mueller, Werner ;

Snapper, Scott B. ;

Schreiber, Stefan ;

Kaser, Arthur ;

Zeissig, Sebastian ;

Blumberg, Richard S. .

NATURE, 2014, 509 (7501) :497-+

[8] Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function [J].

Shouval, Dror S. ;

Biswas, Amlan ;

Goettel, Jeremy A. ;

McCann, Katelyn ;

Conaway, Evan ;

Redhu, Naresh S. ;

Mascanfroni, Ivan D. ;

Al Adham, Ziad ;

Lavoie, Sydney ;

Ibourk, Mouna ;

Nguyen, Deanna D. ;

Samsom, Janneke N. ;

Escher, Johanna C. ;

Somech, Raz ;

Weiss, Batia ;

Beier, Rita ;

Conklin, Laurie S. ;

Ebens, Christen L. ;

Santos, Fernanda G. M. S. ;

Ferreira, Alexandre R. ;

Sherlock, Mary ;

Bhan, Atul K. ;

Mueller, Werner ;

Mora, J. Rodrigo ;

Quintana, Francisco J. ;

Klein, Christoph ;

Muise, Aleixo M. ;

Horwitz, Bruce H. ;

Snapper, Scott B. .

IMMUNITY, 2014, 40 (05) :706-719

[9] RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis [J].

Takahashi, Nozomi ;

Vereecke, Lars ;

Bertrand, Mathieu J. M. ;

Duprez, Linde ;

Berger, Scott B. ;

Divert, Tatyana ;

Goncalves, Amanda ;

Sze, Mozes ;

Gilbert, Barbara ;

Kourula, Stephanie ;

Goossens, Vera ;

Lefebvre, Sylvie ;

Gunther, Claudia ;

Becker, Christoph ;

Bertin, John ;

Gough, Peter J. ;

Declercq, Wim ;

van Loo, Geert ;

Vandenabeele, Peter .

NATURE, 2014, 513 (7516) :95-+

[10] The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis [J].

Turgeon, Naomie ;

Gagne, Julie Moore ;

Blais, Mylene ;

Gendron, Fernand-Pierre ;

Boudreau, Francois ;

Asselin, Claude .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2014, 306 (07) :G594-G605

← 1 →