Additive-Driven Rhodium-Catalyzed [4+1]/[4+2] Annulations of N-Arylphthalazine-1,4-dione with α-Diazo Carbonyl Compounds

被引：41

作者：

Karishma, Pidiyara ^{[1
]}

Mahesha, Chikkagundagal K. ^{[1
]}

Agarwal, Devesh S. ^{[1
]}

Mandal, Sanjay K. ^{[2
]}

Sakhuja, Rajeev ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India

[2] Indian Inst Sci Educ & Res Mohali, Dept Chem Sci, Sect 81,SAS Nagar,Manuali PO, Mohali 140306, Punjab, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 19期

关键词：

C-H ACTIVATION; INTERNAL ALKYNES; DIAZOCARBONYL COMPOUNDS; BIOLOGICAL EVALUATION; OXIDATIVE ANNULATION; IMIDAZO HETEROCYCLES; DERIVATIVES; ACCESS; FUNCTIONALIZATION; DESIGN;

D O I：

10.1021/acs.joc.8b01630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed strategy involving the [4+1] annulation of 2-arylphthalazine-1,4-diones with alpha-diazo carbonyl compounds was developed, accessing a series of unprecedented hydroxy-dihydroindazolo-fused phthalazines in good to excellent yields. By varying the additive, phthalazino-fused cinnolines were synthesized under Rh-catalyzed conditions via [4+2] annulation between the same starting materials. Notably, such two strategies showed a good functional group tolerance and high atom efficiency.

引用

页码：11661 / 11673

页数：13

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