Schwann cell proliferation as the cause of peripheral neuropathy in neurofibromatosis-2

被引：18

作者：

Iwata, A

Kunimoto, M

Inoue, K

机构：

[1] NTT Kanto Teishin Hosp, Dept Neurol, Shinagawa Ku, Tokyo 141, Japan

[2] Yokohama Rosai Hosp, Dept Neurol, Kohoku Ku, Yokohama, Kanagawa 221, Japan

[3] Tokyo Jikeikai Med Coll, Dept Neurol, Minato Ku, Tokyo 105, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 156卷 / 02期

关键词：

neurofibromatosis-2; peripheral neuropathy; Schwannoma; perineurial cells; coreless onion bulb;

D O I：

10.1016/S0022-510X(98)00032-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 18-year-old man who developed slowly progressing right drop foot. Bilateral acoustic neurinoma was found and he was diagnosed as neurofibromatosis-2. Right sural nerve biopsy showed multiple small onion-bulb-like structures in the nerve fascicle. Electronmicroscopic and immunohistochemical studies on this structure confirmed cytological characteristics of Schwann cells, while previous reports suggest that this structure originates from perineural cells. The present report is the first to show both ultrastructurally and immunohistochemically that the onion-bulb-like structure is derived from Schwann cell. (C) 1998 Elsevier Science B.V.

引用

页码：201 / 204

页数：4

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