Guidance on allergenicity assessment of genetically modified plants

被引：208

作者：

Naegeli, Hanspeter

Birch, Andrew Nicholas

Casacuberta, Josep

De Schrijver, Adinda

Gralak, Mikolaj Antoni

Guerche, Philippe

Jones, Huw

Manachini, Barbara

Messean, Antoine

Nielsen, Elsa Ebbesen

Nogue, Fabien

Robaglia, Christophe

Rostoks, Nils

Sweet, Jeremy

Tebbe, Christoph

Visioli, Francesco

Wal, Jean-Michel

Eigenmann, Philippe

Epstein, Michelle

Hoffmann-Sommergruber, Karin

Koning, Frits

Lovik, Martinus

Mills, Clare

Moreno, Francisco Javier

van Loveren, Henk

Selb, Regina

Dumont, Antonio Fernandez

机构：

来源：

EFSA JOURNAL | 2017年 / 15卷 / 06期

关键词：

guidance; allergenicity assessment; newly expressed proteins; endogenous allergenicity; GMO; BOVINE BETA-LACTOGLOBULIN; SIMULATED GASTRIC FLUID; IN-VITRO DIGESTIBILITY; GLY M 4; FOOD ALLERGENS; CELIAC-DISEASE; ENDOGENOUS ALLERGENS; INTESTINAL DIGESTION; SENSITIZING CAPACITY; PROTEOMIC ANALYSIS;

D O I：

10.2903/j.efsa.2017.4862

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non-IgE-mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate. (C) 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

引用

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