Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats

被引：9

作者：

Azova, M. M. ^{[1
]}

Blagonravov, M. L. ^{[1
]}

Frolov, V. A. ^{[1
]}

机构：

[1] Peoples Friendship Univ Russia, Dept Gen Pathol & Pathophysiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 158卷 / 03期

关键词：

apoptosis; hypertension; cardiomyocyte; phosphocreatine; mexidol; ARTERIAL-HYPERTENSION; MYOCARDIAL-CELLS; APOPTOSIS; MITOCHONDRIA; DEATH;

D O I：

10.1007/s10517-015-2749-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats (SHR). Both drugs have no effect on the expression of Bcl-2, but significantly reduce the level of Bax protein (phosphocreatine produces more pronounced effect). These data attest to an important role of energy deficit and oxidative stress in the induction of cardiomyocyte apoptosis in genetically determined arterial hypertension.

引用

页码：313 / 314

页数：2

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