Decreased Gray Matter Concentration in the Lateral Geniculate Nuclei in Human Amblyopes

被引：84

作者：

Barnes, Gareth R. ^{[2
]}

Li, Xingfeng ^{[1
]}

Thompson, Benjamin ^{[1
]}

Singh, Krishna D. ^{[3
]}

Dumoulin, Serge O. ^{[4
]}

Hess, Robert F. ^{[1
]}

机构：

[1] McGill Univ, McGill Vis Res Unit, Dept Ophthalmol, Montreal, PQ H3A 1A1, Canada

[2] Inst Neurol, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England

[3] Cardiff Univ, CUBRIC, Sch Psychol, Cardiff, S Glam, Wales

[4] Univ Utrecht, Helmholtz Inst, Utrecht, Netherlands

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2010年 / 51卷 / 03期

基金：

加拿大健康研究院;

关键词：

VOXEL-BASED MORPHOMETRY; RETINAL GANGLION-CELLS; HUMAN VISUAL-CORTEX; STRABISMIC AMBLYOPIA; ANISOMETROPIC AMBLYOPIA; BINOCULAR COMPETITION; SPATIAL-RESOLUTION; CATS; ACTIVATION; ADULTS;

D O I：

10.1167/iovs.09-3931

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomalies in the visual cortex correlate with the previously reported cortical functional losses? (3) Is there a link between the functional anomalies in the visual cortex and any structural anomalies in the geniculate? METHODS. The structure was compared by using voxel-based morphometry (VBM) and the function by functional magnetic resonance imaging (fMRI). RESULTS. The results showed that the geniculate is structurally abnormal in humans with strabismic amblyopia. CONCLUSIONS. These findings add further weight to the role of the LGN in the cortical deficits exhibited in human strabismic amblyopes. (Invest Ophthalmol Vis Sci. 2010; 51: 1432-1438) DOI: 10.1167/iovs.09-3931

引用

页码：1432 / 1438

页数：7

共 48 条

[1]

Andrews TJ, 1997, J NEUROSCI, V17, P2859

[2]

[Anonymous], LINEAR REGRESSION AN

[3] Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[4] The cortical deficit in humans with strabismic amblyopia [J].

Barnes, GR ;

Hess, RF ;

Dumoulin, SO ;

Achtman, RL ;

Pike, GB .

JOURNAL OF PHYSIOLOGY-LONDON, 2001, 533 (01) :281-297

[5] EFFECTS OF VISUAL DEPRIVATION ON THE DEVELOPMENT OF THE MONKEYS LATERAL GENICULATE-NUCLEUS [J].

BLAKEMORE, C ;

VITALDURAND, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 380 :493-511

[6] Neuroanatomy of adult strabismus: a voxel-based morphometric analysis of magnetic resonance structural scans [J].

Chan, ST ;

Tang, KW ;

Lam, KC ;

Chan, LK ;

Mendola, JD ;

Kwong, KK .

NEUROIMAGE, 2004, 22 (02) :986-994

[7] VISUAL RESOLUTION OF RETINAL GANGLION-CELLS IN MONOCULARLY-DEPRIVED CATS [J].

CLELAND, BG ;

MITCHELL, DE ;

GILLARDCREWTHER, S ;

CREWTHER, DP .

BRAIN RESEARCH, 1980, 192 (01) :261-266

[8] NORMALITY OF SPATIAL-RESOLUTION OF RETINAL GANGLION-CELLS IN CATS WITH STRABISMIC AMBLYOPIA [J].

CLELAND, BG ;

CREWTHER, DP ;

CREWTHER, SG ;

MITCHELL, DE .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 326 (MAY) :235-249

[9] A fully automatic and robust brain MRI tissue classification method [J].

Cocosco, CA ;

Zijdenbos, AP ;

Evans, AC .

MEDICAL IMAGE ANALYSIS, 2003, 7 (04) :513-527

[10] AUTOMATIC 3D INTERSUBJECT REGISTRATION OF MR VOLUMETRIC DATA IN STANDARDIZED TALAIRACH SPACE [J].

COLLINS, DL ;

NEELIN, P ;

PETERS, TM ;

EVANS, AC .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1994, 18 (02) :192-205

← 1 2 3 4 5 →