Structural Plasticity of the Ventral Stream and Aphasia Recovery

被引：42

作者：

McKinnon, Emilie T. ^{[1
,2
,3
]}

Fridriksson, Julius ^{[4
]}

Glenn, G. Russell ^{[2
,3
,5
]}

Jensen, Jens H. ^{[2
,3
]}

Helpern, Joseph A. ^{[1
,2
,3
,5
]}

Basilakos, Alexandra ^{[4
]}

Rorden, Chris ^{[6
]}

Shih, Andy Y. ^{[5
]}

Spampinato, M. Vittoria ^{[3
]}

Bonilha, Leonardo ^{[1
]}

机构：

[1] Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Ctr Biomed Imaging, Charleston, SC USA

[3] Med Univ South Carolina, Dept Radiol & Radiol Sci, Charleston, SC USA

[4] Univ South Carolina, Dept Commun Sci & Disorders, Columbia, SC USA

[5] Med Univ South Carolina, Dept Neurosci, Charleston, SC USA

[6] Univ South Carolina, Dept Psychol, Columbia, SC USA

来源：

ANNALS OF NEUROLOGY | 2017年 / 82卷 / 01期

关键词：

MATTER; THERAPY; STROKE;

D O I：

10.1002/ana.24983

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Restrengthening of the residual language network is likely to be crucial for speech recovery in poststroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for 3 weeks, with standardized naming tests and brain magnetic resonance imaging before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal fasciculus (ILF). Therapy-related reduction in the number of semantic but not phonemic errors was associated with strengthening (renormalization) of ILF MK (r = -0.90, p < 0.05 corrected), suggesting that speech recovery is related to structural plasticity of language-specific components of the residual language network.

引用

页码：147 / 151

页数：5

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